Structure information

SST2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7XN9

SPECIES

Homo sapiens

RESOLUTION

2.600

PREFERRED CHAIN

A

REFERENCE

10.1038/S41422-022-00679-X

PUBLICATION DATE

Aug. 3, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
L-054,522 Y50 1.39x39 TM1 polar (hydrogen bond)
L-054,522 F92 2.53x53 TM2 Van der Waals
L-054,522 L99 2.60x60 TM2 Van der Waals
L-054,522 L99 2.60x60 TM2 polar (hydrogen bond with backbone)
L-054,522 Q102 2.63x63 TM2 polar (hydrogen bond)
L-054,522 V103 2.64x64 TM2 Van der Waals
L-054,522 M119 3.29x29 TM3 Van der Waals
L-054,522 D122 3.32x32 TM3 polar (charge-assisted hydrogen bond)
L-054,522 Q126 3.36x36 TM3 polar (hydrogen bond)
L-054,522 F127 3.37x37 TM3 Van der Waals
L-054,522 I177 4.60x61 TM4 Van der Waals
L-054,522 T194 45.51x51 ECL2 polar (hydrogen bond)
L-054,522 T194 45.51x51 ECL2 Van der Waals
L-054,522 I195 45.52x52 ECL2 Van der Waals
L-054,522 I195 45.52x52 ECL2 hydrophobic
L-054,522 Y205 5.35x36 TM5 polar (hydrogen bond)
L-054,522 F208 5.38x39 TM5 Van der Waals
L-054,522 F208 5.38x39 TM5 aromatic (edge-to-face)
L-054,522 T212 5.42x43 TM5 polar (hydrogen bond)
L-054,522 W269 6.48x48 TM6 Van der Waals
L-054,522 F272 6.51x51 TM6 hydrophobic
L-054,522 F272 6.51x51 TM6 Van der Waals
L-054,522 Y273 6.52x52 TM6 Van der Waals
L-054,522 F275 6.54x54 TM6 aromatic (edge-to-face)
L-054,522 F275 6.54x54 TM6 Van der Waals
L-054,522 N276 6.55x55 TM6 polar (hydrogen bond)
L-054,522 S279 6.58x58 TM6 polar (hydrogen bond)
L-054,522 A283 ECL3 polar (hydrogen bond with backbone)
L-054,522 A283 ECL3 Van der Waals
L-054,522 I284 ECL3 Van der Waals
L-054,522 I284 ECL3 polar (hydrogen bond with backbone)
L-054,522 S285 ECL3 Van der Waals
L-054,522 S285 ECL3 polar (hydrogen bond with backbone)
L-054,522 P286 ECL3 Van der Waals
L-054,522 P286 ECL3 hydrophobic
L-054,522 T287 7.28x27 TM7 Van der Waals
L-054,522 L290 7.31x30 TM7 Van der Waals
L-054,522 L290 7.31x30 TM7 polar (hydrogen bond with backbone)
L-054,522 K291 7.32x31 TM7 polar (hydrogen bond with backbone)
L-054,522 K291 7.32x31 TM7 Van der Waals
L-054,522 F294 7.35x34 TM7 Van der Waals
L-054,522 F294 7.35x34 TM7 aromatic (face-to-edge)
L-054,522 D295 7.36x35 TM7 polar (charge-assisted hydrogen bond)
L-054,522 V298 7.39x38 TM7 hydrophobic
L-054,522 V298 7.39x38 TM7 Van der Waals
L-054,522 Y302 7.43x42 TM7 polar (hydrogen bond)

Ligands

L-054,522

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Residue Diagrams

T N G C L G I I C V V F Y I F T L V A N 1 L N L A I A D E L F M L G L P F L A M Q 2 V T L C F I S T F Q N I G D V T M V V R 3 A K M I T M A V W G V S L L V I L P I 4 Y C L C I I T L P V L F G L I F T Y I I F 5 S I V V A V F I F C W L P F Y I F N V S 6 I P N A C S N A Y T L V V V F D F M G 7
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ICL1 A K M K ICL1ECL1 V H W P F ECL1ICL2 P I K S A K W R ICL2ECL2 G L R S N Q W G R S S C T I N W P G E ECL2ICL3 G I R V G ICL3ECL3 A I S P ECL3N-term M D M A D E P L N G S H T W L S I P F D L N G S V V S T N T S N Q T E P Y Y D N-termC-term L V K V S G T D D G E R S D S K Q D K S R L N E T T E T Q R T L L N G D L Q T S I C-term L T S N A V L T F I Y F V V C I I G L C G N T L V I Y V I L R Y T I T N I Y I L N L A I A D E L F M L G L P F L A M Q V A L G K A I C R V V M T V D G I N Q F T S I F C L T V M S I D R Y L A V V H R P R T A K M I T M A V W G V S L L V I L P I M I Y A S G A W Y T G F I I Y T F I L G F L V P L T I I C L C Y L F I I I K V K S S S S K R K K S E K K V T R M V S I V V A V F I F C W L P F Y I F N V S S V S M T P A L K G M F D F V V V L T Y A N S C A N P I L Y A F L S D N F Q N F K K S V L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
SST2 receptor
TM1
1x39 1.39x39 Y50
TM2
2x53 2.53x53 F92
2x60 2.60x60 L99
2x63 2.63x63 Q102
2x64 2.64x64 V103
TM3
3x29 3.29x29 M119
3x32 3.32x32 D122
3x36 3.36x36 Q126
3x37 3.37x37 F127
TM4
4x61 4.60x61 I177
ECL2
45x51 45.51x51 T194
45x52 45.52x52 I195
TM5
5x36 5.35x36 Y205
5x39 5.38x39 F208
5x43 5.42x43 T212
TM6
6x48 6.48x48 W269
6x51 6.51x51 F272
6x52 6.52x52 Y273
6x54 6.54x54 F275
6x55 6.55x55 N276
6x58 6.58x58 S279
TM7
7x27 7.28x27 T287
7x30 7.31x30 L290
7x31 7.32x31 K291
7x34 7.35x34 F294
7x35 7.36x35 D295
7x38 7.39x38 V298
7x42 7.43x42 Y302