Structure information

SST2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7XNA

SPECIES

Homo sapiens

RESOLUTION

2.650

PREFERRED CHAIN

A

REFERENCE

10.1038/S41422-022-00679-X

PUBLICATION DATE

Aug. 3, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CYN 154806 N43 1.32x32 TM1 polar (hydrogen bond)
CYN 154806 N43 1.32x32 TM1 polar (hydrogen bond)
CYN 154806 V103 2.64x64 TM2 Van der Waals
CYN 154806 V103 2.64x64 TM2 hydrophobic
CYN 154806 E106 ECL1 Van der Waals
CYN 154806 M119 3.29x29 TM3 polar (hydrogen bond)
CYN 154806 D122 3.32x32 TM3 polar (charge-assisted hydrogen bond)
CYN 154806 Q126 3.36x36 TM3 polar (hydrogen bond)
CYN 154806 S192 ECL2 Van der Waals
CYN 154806 T194 45.51x51 ECL2 Van der Waals
CYN 154806 I195 45.52x52 ECL2 hydrophobic
CYN 154806 I195 45.52x52 ECL2 Van der Waals
CYN 154806 Y205 5.35x36 TM5 Van der Waals
CYN 154806 Y205 5.35x36 TM5 hydrophobic
CYN 154806 F208 5.38x39 TM5 hydrophobic
CYN 154806 F208 5.38x39 TM5 Van der Waals
CYN 154806 F275 6.54x54 TM6 hydrophobic
CYN 154806 F275 6.54x54 TM6 Van der Waals
CYN 154806 M282 ECL3 Van der Waals
CYN 154806 P286 ECL3 Van der Waals
CYN 154806 P286 ECL3 hydrophobic
CYN 154806 L290 7.31x30 TM7 polar (hydrogen bond with backbone)
CYN 154806 L290 7.31x30 TM7 Van der Waals
CYN 154806 K291 7.32x31 TM7 Van der Waals
CYN 154806 K291 7.32x31 TM7 polar (hydrogen bond with backbone)
CYN 154806 F294 7.35x34 TM7 Van der Waals
CYN 154806 F294 7.35x34 TM7 hydrophobic
CYN 154806 D295 7.36x35 TM7 polar (charge-assisted hydrogen bond)
CYN 154806 V298 7.39x38 TM7 Van der Waals
CYN 154806 V298 7.39x38 TM7 hydrophobic
CYN 154806 Y302 7.43x42 TM7 Van der Waals

Ligands

CYN 154806

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Residue Diagrams

T N G C L G I I C V V F Y I F T L V A N 1 L N L A I A D E L F M L G L P F L A M Q 2 V T L C F I S T F Q N I G D V T M V V R 3 A K M I T M A V W G V S L L V I L P I 4 Y C L C I I T L P V L F G L I F T Y I I F 5 S I V V A V F I F C W L P F Y I F N V S 6 I P N A C S N A Y T L V V V F D F M G 7
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ICL1 A K M K ICL1ECL1 V H W P F ECL1ICL2 P I K S A K W R ICL2ECL2 G L R S N Q W G R S S C T I N W P G E ECL2ICL3 G I R V G ICL3ECL3 A I S P ECL3N-term M D M A D E P L N G S H T W L S I P F D L N G S V V S T N T S N Q T E P Y Y D N-termC-term L V K V S G T D D G E R S D S K Q D K S R L N E T T E T Q R T L L N G D L Q T S I C-term L T S N A V L T F I Y F V V C I I G L C G N T L V I Y V I L R Y T I T N I Y I L N L A I A D E L F M L G L P F L A M Q V A L G K A I C R V V M T V D G I N Q F T S I F C L T V M S I D R Y L A V V H R P R T A K M I T M A V W G V S L L V I L P I M I Y A S G A W Y T G F I I Y T F I L G F L V P L T I I C L C Y L F I I I K V K S S S S K R K K S E K K V T R M V S I V V A V F I F C W L P F Y I F N V S S V S M T P A L K G M F D F V V V L T Y A N S C A N P I L Y A F L S D N F Q N F K K S V L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
SST2 receptor
TM1
1x32 1.32x32 N43
TM2
2x64 2.64x64 V103
TM3
3x29 3.29x29 M119
3x32 3.32x32 D122
3x36 3.36x36 Q126
ECL2
45x51 45.51x51 T194
45x52 45.52x52 I195
TM5
5x36 5.35x36 Y205
5x39 5.38x39 F208
TM6
6x54 6.54x54 F275
TM7
7x30 7.31x30 L290
7x31 7.32x31 K291
7x34 7.35x34 F294
7x35 7.36x35 D295
7x38 7.39x38 V298
7x42 7.43x42 Y302