Structure information

CCK1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7XOV

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

R

REFERENCE

10.1038/S41421-022-00420-3

PUBLICATION DATE

July 20, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
SR146131 L99 2.62x61 TM2 hydrophobic
SR146131 M121 3.32x32 TM3 hydrophobic
SR146131 Y176 4.60x61 TM4 aromatic (face-to-edge)
SR146131 Y179 4.63x64 TM4 hydrophobic
SR146131 R197 45.51x51 ECL2 polar (charge-assisted hydrogen bond)
SR146131 I329 6.51x51 TM6 Van der Waals
SR146131 F330 6.52x52 TM6 hydrophobic
SR146131 F330 6.52x52 TM6 Van der Waals
SR146131 A332 6.54x54 TM6 Van der Waals
SR146131 N333 6.55x55 TM6 polar (hydrogen bond)
SR146131 R336 6.58x58 TM6 polar (charge-assisted hydrogen bond)
SR146131 A343 ECL3 hydrophobic
SR146131 A343 ECL3 Van der Waals
SR146131 E344 ECL3 Van der Waals
SR146131 L347 ECL3 hydrophobic
SR146131 L347 ECL3 Van der Waals
SR146131 I352 7.35x34 TM7 Van der Waals
SR146131 I352 7.35x34 TM7 hydrophobic
SR146131 L356 7.39x38 TM7 hydrophobic
SR146131 L356 7.39x38 TM7 Van der Waals
SR146131 S359 7.42x41 TM7 Van der Waals
SR146131 Y360 7.43x42 TM7 Van der Waals
SR146131 Y360 7.43x42 TM7 hydrophobic

Ligands

SR146131

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Residue Diagrams

T N G L V S L L F I L S Y L L I Q V A P 1 L S L A V S D L M L C F L C M P F N L I P 2 A V L N F T S V S V S T G M F Y T T T K 3 A L K V I A A T W C L S F T I M T P Y 4 Y A V M M V I G P I L F L I L L L F T H W 5 I V I V V L F F L C W M P I F S A N A W 6 I P N V C S S T Y S L L L I F S I P T 7
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ICL1 K R M R ICL1ECL1 D F I F ECL1ICL2 P L Q S R V W Q ICL2ECL2 N L V P F T K N N N Q T A N M C R F L L P ECL2ICL3 Q K K S A K E R K P S T T S S G K Y E D S D G C Y L Q K T R P P R K L E L R Q L S T G S S S R A N R I R S N S ICL3ECL3 T A S A E R R L S ECL3N-term M D V V D S L L V N G S N I T P P C E L G L E N E T L F C L D Q P R P S K E N-termC-term P G P P G A R G E V G E E E E G G T T G A S L S R F S Y S H M S A S V P P Q C-term W Q P A V Q I L L Y S L I F L L S V L G N T L V I T V L I R N T V T N I F L L S L A V S D L M L C L F C M P F N L I P N L L K G S A V C K T T T Y F M G T S V S V S T F N L V A I S L E R Y G A I C K T K S H A L K V I A A T W C L S F T I M T P Y P I Y S N D V M Q Q S W H T F L L L I L F L I P G I V M M V A Y G L I S L E L Y Q G I K F E A S S A A N L M A K K R V I R M L I V I V V L F F L C W M P I F S A N A W R A Y D G T P I S F I L L L S Y T S S C V N P I I Y C F M N K R F M A C P N F R L G T F P C
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Residue Table


GPCRdb(A)
GPCRdb(A)
CCK1 receptor
TM2
2x61 2.62x61 L99
TM3
3x32 3.32x32 M121
TM4
4x61 4.60x61 Y176
4x64 4.63x64 Y179
ECL2
45x51 45.51x51 R197
TM6
6x51 6.51x51 I329
6x52 6.52x52 F330
6x54 6.54x54 A332
6x55 6.55x55 N333
6x58 6.58x58 R336
TM7
7x34 7.35x34 I352
7x38 7.39x38 L356
7x41 7.42x41 S359
7x42 7.43x42 Y360