Structure information

OX2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7XRR

SPECIES

Homo sapiens

RESOLUTION

2.890

PREFERRED CHAIN

A

PUBLICATION DATE

Nov. 23, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
lemborexant V114 2.64x63 TM2 hydrophobic
lemborexant P131 3.29x29 TM3 hydrophobic
lemborexant Q134 3.32x32 TM3 polar (hydrogen bond)
lemborexant Q134 3.32x32 TM3 polar (hydrogen bond)
lemborexant Q187 4.60x61 TM4 Van der Waals
lemborexant F227 5.42x43 TM5 Van der Waals
lemborexant F227 5.42x43 TM5 aromatic (edge-to-face)
lemborexant I320 6.51x51 TM6 hydrophobic
lemborexant I320 6.51x51 TM6 Van der Waals
lemborexant N324 6.55x55 TM6 Van der Waals
lemborexant H350 7.39x38 TM7 aromatic (face-to-face)
lemborexant H350 7.39x38 TM7 Van der Waals

Ligands

lemborexant

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Residue Diagrams

V N G I L A V V F V I I Y G A I L V W E 1 V N L S L A D V L V T T I C L P A T L V V 2 C S L T L V S V S V S V T Q L Y P I V K 3 A R N S I V I I W I V S C I I M I P Q 4 Y A L V M L C L P A M Y T V L F F C I H Y 5 M I V L L V F A I C Y L P I S I L N V L 6 I P N A A S N A Y V L W H S F T F W A 7
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ICL1 H H M R ICL1ECL1 T W F F ECL1ICL2 P L M F K S ICL2ECL2 E C S T V F P G L A N K T T L F T V C D E R W G G E ECL2ICL3 G T S S V V Q R K W K P L Q P V S Q P R G P G Q P T K S R M S A ICL3ECL3 G M F A H T E ECL3N-term M S G T K L E D S P P C R N W S S A S E L N E T Q E P F L N P T D Y D D E E F L R Y L W R E Y L H P K E N-termC-term G V H H R Q E D R L T R G R T S T E S R K S L T T Q I S N F D N I S K L S E Q V V L T S I S T L P A A N G A G P L Q N W C-term Y E W V L I A G Y I I V F V V A L I G N V L V C V A V W K N T V T N Y F I V N L S L A D V L V T I T C L P A T L V V D I T E G Q S L C K V I P Y L Q T V S V S V S V L T L S C I A L D R W Y A I C H T A K R A R N S I V I I W I V S C I I M I P Q A I V M I Y P K M Y H I C F F L V T Y M A P L C L M V L A Y L Q I F R K L W C R Q I P V A A E I K Q I R A R R K T A R M L M I V L L V F A I C Y L P I S I L N V L K R V F D R E T V Y A W F T F S H W L V Y A N S A A N P I I Y N F L S G K F K A C C L F R E E A F S C
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Residue Table


GPCRdb(A)
GPCRdb(A)
OX2 receptor
TM2
2x63 2.64x63 V114
TM3
3x29 3.29x29 P131
3x32 3.32x32 Q134
TM4
4x61 4.60x61 Q187
TM5
5x43 5.42x43 F227
TM6
6x51 6.51x51 I320
6x55 6.55x55 N324
TM7
7x38 7.39x38 H350