Ligand
Function
Agonist
Reference
| Ligand | Amino Acid | Generic Number | Segment | Interaction Type |
|---|---|---|---|---|
| LysoPS(18:0) | R18 | 1.31x31 | TM1 | polar (charge-charge) |
| LysoPS(18:0) | Y22 | 1.35x35 | TM1 | aromatic (pi-cation) |
| LysoPS(18:0) | Y26 | 1.39x39 | TM1 | Van der Waals |
| LysoPS(18:0) | R75 | 2.60x60 | TM2 | polar (hydrogen bond) |
| LysoPS(18:0) | R75 | 2.60x60 | TM2 | polar (charge-charge) |
| LysoPS(18:0) | Y79 | 2.64x64 | TM2 | Van der Waals |
| LysoPS(18:0) | F95 | 3.29x29 | TM3 | Van der Waals |
| LysoPS(18:0) | Y99 | 3.33x33 | TM3 | polar (hydrogen bond) |
| LysoPS(18:0) | Y103 | 3.37x37 | TM3 | Van der Waals |
| LysoPS(18:0) | I106 | 3.40x40 | TM3 | hydrophobic |
| LysoPS(18:0) | Y107 | 3.41x41 | TM3 | hydrophobic |
| LysoPS(18:0) | I145 | 4.53x53 | TM4 | Van der Waals |
| LysoPS(18:0) | C149 | 4.57x57 | TM4 | Van der Waals |
| LysoPS(18:0) | L151 | 4.59x59 | TM4 | Van der Waals |
| LysoPS(18:0) | F152 | 4.60x60 | TM4 | hydrophobic |
| LysoPS(18:0) | L155 | 4.63x63 | TM4 | Van der Waals |
| LysoPS(18:0) | R156 | 4.64x64 | TM4 | polar (charge-charge) |
| LysoPS(18:0) | R156 | 4.64x64 | TM4 | polar (hydrogen bond) |
| LysoPS(18:0) | F169 | 45.51x51 | ECL2 | polar (hydrogen bond with backbone) |
| LysoPS(18:0) | G189 | 5.42x43 | TM5 | Van der Waals |
| LysoPS(18:0) | I192 | 5.45x46 | TM5 | Van der Waals |
| LysoPS(18:0) | G193 | 5.46x461 | TM5 | Van der Waals |
| LysoPS(18:0) | P197 | 5.50x50 | TM5 | Van der Waals |
| LysoPS(18:0) | Y246 | 6.51x51 | TM6 | polar (hydrogen bond) |
| LysoPS(18:0) | F250 | 6.55x55 | TM6 | hydrophobic |
| LysoPS(18:0) | F254 | 6.59x59 | TM6 | hydrophobic |
| LysoPS(18:0) | K257 | 6.62x62 | TM6 | polar (hydrogen bond) |
| LysoPS(18:0) | K257 | 6.62x62 | TM6 | polar (charge-charge) |
| LysoPS(18:0) | H274 | 7.35x34 | TM7 | Van der Waals |
| LysoPS(18:0) | L278 | 7.39x38 | TM7 | Van der Waals |
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|
GPCRdb(A)
|
GPCRdb(A)
|
GPR174
|
|---|---|---|
| TM1 | ||
| 1x31 | 1.31x31 | R18 |
| 1x35 | 1.35x35 | Y22 |
| 1x39 | 1.39x39 | Y26 |
| TM2 | ||
| 2x60 | 2.60x60 | R75 |
| 2x64 | 2.64x64 | Y79 |
| TM3 | ||
| 3x29 | 3.29x29 | F95 |
| 3x33 | 3.33x33 | Y99 |
| 3x37 | 3.37x37 | Y103 |
| 3x40 | 3.40x40 | I106 |
| 3x41 | 3.41x41 | Y107 |
| TM4 | ||
| 4x53 | 4.53x53 | I145 |
| 4x57 | 4.57x57 | C149 |
| 4x59 | 4.59x59 | L151 |
| 4x60 | 4.60x60 | F152 |
| 4x63 | 4.63x63 | L155 |
| 4x64 | 4.64x64 | R156 |
| ECL2 | ||
| 45x51 | 45.51x51 | F169 |
| TM5 | ||
| 5x43 | 5.42x43 | G189 |
| 5x46 | 5.45x46 | I192 |
| 5x461 | 5.46x461 | G193 |
| 5x50 | 5.50x50 | P197 |
| TM6 | ||
| 6x51 | 6.51x51 | Y246 |
| 6x55 | 6.55x55 | F250 |
| 6x59 | 6.59x59 | F254 |
| 6x62 | 6.62x62 | K257 |
| TM7 | ||
| 7x34 | 7.35x34 | H274 |
| 7x38 | 7.39x38 | L278 |