Structure information

A2B receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7XY7

SPECIES

Homo sapiens

RESOLUTION

3.260

PREFERRED CHAIN

R

REFERENCE

10.1126/SCIADV.ADD3709

PUBLICATION DATE

May 3, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
NECA F173 45.52x52 ECL2 aromatic (face-to-face)
NECA M182 5.38x40 TM5 polar (hydrogen bond)
NECA W247 6.48x48 TM6 Van der Waals
NECA W247 6.48x48 TM6 hydrophobic
NECA V250 6.51x51 TM6 Van der Waals
NECA H251 6.52x52 TM6 Van der Waals
NECA N254 6.55x55 TM6 Van der Waals
NECA M272 7.35x34 TM7 Van der Waals
NECA M272 7.35x34 TM7 hydrophobic
NECA I276 7.39x38 TM7 hydrophobic
NECA I276 7.39x38 TM7 Van der Waals
NECA S279 7.42x41 TM7 polar (hydrogen bond)
NECA S279 7.42x41 TM7 Van der Waals
NECA H280 7.43x42 TM7 polar (hydrogen bond)
NECA H280 7.43x42 TM7 Van der Waals

Ligands

NECA

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Residue Diagrams

V N G A V S L A A I V L E L A V Y L A D 1 V S L A A A D V A V G F L A I P F A I T I 2 A L L S F I S S Q T L V L V F C A L F L 3 A R G V I A V L W V L A F G I G L T P F 4 Y I V L M I L L P P L V C G F F N F Y V M Y 5 A M I V G I F A L C W L P V H A V N C V 6 I P N V V S N A H S L L I A M N M A W 7
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ICL1 N T L Q ICL1ECL1 F C T ECL1ICL2 P L R Y K S L V ICL2ECL2 W N S K D S A T N N C T E P W D G T T N E S C C L V K C L F E N V V ECL2ICL3 L M D ICL3ECL3 P A Q G K N K ECL3N-term M L L N-termC-term S G N G Q A G V Q P A L G V G L C-term E T Q D A L Y V A L E L V I A A L S V A G N V L V C A A V G T A T P T N Y F L V S L A A A D V A V G L F A I P F A I T I S L G D F Y G C L F L A C F V L V L T Q S S I F S L L A V A V D R Y L A I C V T G T R A R G V I A V L W V L A F G I G L T P F L G P M S Y M V Y F N F F G C V L P P L L I M L V I Y I K I F L V A C R Q L Q R T E H S R T T L Q R E I H A A K S L A M I V G I F A L C W L P V H A V N C V T L F Q P K W A M N M A I L L S H A N S V V N P I V Y A Y R N R D F H K Y L L V K F R Y T I I S R C Q A D
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Residue Table


GPCRdb(A)
GPCRdb(A)
A2B receptor
ECL2
45x52 45.52x52 F173
TM5
5x40 5.38x40 M182
TM6
6x48 6.48x48 W247
6x51 6.51x51 V250
6x52 6.52x52 H251
6x55 6.55x55 N254
TM7
7x34 7.35x34 M272
7x38 7.39x38 I276
7x41 7.42x41 S279
7x42 7.43x42 H280