PDB
7Y36
Resolution
2.8 Å
Released
July 5, 2023
Receptor
PTH1
Class
B1
Species
Homo sapiens
Ligand
PTH
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
PTH M32 N-term polar (hydrogen bond with backbone)
PTH M32 N-term Van der Waals
PTH T33 N-term polar (hydrogen bond with backbone)
PTH T33 N-term Van der Waals
PTH K34 N-term polar (charge-assisted hydrogen bond)
PTH Q37 N-term Van der Waals
PTH I38 N-term hydrophobic
PTH I38 N-term Van der Waals
PTH L41 N-term Van der Waals
PTH L41 N-term hydrophobic
PTH D113 N-term Van der Waals
PTH H114 N-term Van der Waals
PTH I115 N-term Van der Waals
PTH I115 N-term hydrophobic
PTH I135 N-term hydrophobic
PTH I135 N-term Van der Waals
PTH Y136 N-term Van der Waals
PTH D137 N-term polar (charge-assisted hydrogen bond)
PTH F138 N-term hydrophobic
PTH F138 N-term Van der Waals
PTH R162 N-term polar (charge-assisted hydrogen bond)
PTH A165 N-term Van der Waals
PTH A165 N-term polar (hydrogen bond with backbone)
PTH Y167 N-term aromatic (edge-to-face)
PTH Y167 N-term Van der Waals
PTH V171 N-term hydrophobic
PTH L174 N-term Van der Waals
PTH L174 N-term hydrophobic
PTH T175 N-term polar (hydrogen bond)
PTH T175 N-term Van der Waals
PTH E180 1.32x32 TM1 polar (charge-assisted hydrogen bond)
PTH F184 1.36x36 TM1 hydrophobic
PTH F184 1.36x36 TM1 Van der Waals
PTH Y195 1.47x47 TM1 polar (hydrogen bond)
PTH R233 2.60x60 TM2 Van der Waals
PTH Y245 2.72x72 TM2 hydrophobic
PTH Y245 2.72x72 TM2 Van der Waals
PTH F288 3.36x36 TM3 hydrophobic
PTH F288 3.36x36 TM3 Van der Waals
PTH L289 3.37x37 TM3 Van der Waals
PTH L289 3.37x37 TM3 hydrophobic
PTH L292 3.40x40 TM3 hydrophobic
PTH L292 3.40x40 TM3 Van der Waals
PTH Y296 3.44x44 TM3 Van der Waals
PTH D353 45.52x52 ECL2 Van der Waals
PTH D353 45.52x52 ECL2 polar (hydrogen bond with backbone)
PTH L354 ECL2 Van der Waals
PTH L354 ECL2 hydrophobic
PTH S355 ECL2 polar (hydrogen bond with backbone)
PTH S355 ECL2 Van der Waals
PTH Q364 5.40x40 TM5 Van der Waals
PTH L368 5.44x44 TM5 Van der Waals
PTH F424 6.56x56 TM6 Van der Waals
PTH F424 6.56x56 TM6 polar (hydrogen bond with backbone)
PTH M425 ECL3 Van der Waals
PTH M425 ECL3 polar (hydrogen bond with backbone)
PTH T427 ECL3 polar (hydrogen bond with backbone)
PTH T427 ECL3 Van der Waals
PTH P428 ECL3 Van der Waals
PTH Y429 ECL3 hydrophobic
PTH Y429 ECL3 Van der Waals
PTH V432 ECL3 Van der Waals
PTH W437 7.35x34 TM7 polar (hydrogen bond)
PTH W437 7.35x34 TM7 Van der Waals
PTH Q440 7.38x37 TM7 polar (hydrogen bond)
PTH Q440 7.38x37 TM7 Van der Waals
PTH M441 7.39x38 TM7 hydrophobic
PTH M441 7.39x38 TM7 Van der Waals
PTH E444 7.42x41 TM7 Van der Waals
PTH M445 7.43x42 TM7 hydrophobic
PTH M445 7.43x42 TM7 Van der Waals
PTH N448 7.46x45 TM7 polar (hydrogen bond)
PTH N448 7.46x45 TM7 Van der Waals

PTH

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Snake plot — Download: PNG | SVG
ICL1 R R L H ICL1ECL1 L D E A E R L T E E E L R A I A Q A P P P P A T A A A ECL1ICL2 A F F ICL2ECL2 N T G C W D L S S ECL2ICL3 R E T N A G R C ICL3ECL3 P Y T E V S ECL3N-term M G T A R I A P G L A L L L C C P V L S S A Y A L V D A D D V M T K E E Q I F L L H R A Q A Q C E K R L K E V L Q R P A S I M E S D K G W T S A S T S G K P R K D K A S G K L Y P E S E E D K E A P T G S R Y R G R P C L P E W D H I L C W P L G A P G E V V A V P C P D Y I Y D F N H K G H A Y R R C D R N G S W E L V P G H N R T W A N Y S E C V K N-termC-term S G S S S Y S Y G P M V S H T S V T N V G P R V G L G L P L S P R L L P T A T T N G H P Q L P G H A K P G T P A L E T L E T T P P A M A A P K D D G F L N G S C S G L D E E A S G P E R P P A L L Q E E W E T V M C-term F L T N E T R E R E V F D R L G M I Y T V G Y S V S L A S L T V A V L I L A Y F C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S G A T G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L D T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T G T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E I K K W T L K R K V Q A E S W S R A L D F A R
Helix box plot — Download: PNG | SVG T L S A L S V S Y G V T Y I M G L R D F 1 M H L F L S F M L R A V S I F V K D A V 2 V L I W Y Y N T A L F Y L F F T V A V R 3 Y L W G F T V G F W G L P A V F V A V W V 4 F L I F N L V I S A L I P V Q I I W K K N 5 L V L M P L F G V H Y I V F M A T 6 I A V F F G Q F S N F L M E Y H M Q V 7

GPCRdb(A)
GPCRdb(B)
PTH1 receptor
TM1
1x28 1.32x32 E180
1x32 1.36x36 F184
1x43 1.47x47 Y195
TM2
2x53 2.60x60 R233
2x65 2.72x72 Y245
TM3
3x32 3.36x36 F288
3x33 3.37x37 L289
3x36 3.40x40 L292
3x40 3.44x44 Y296
ECL2
45x52 45.52x52 D353
TM5
5x44 5.40x40 Q364
5x48 5.44x44 L368
TM6
6x51 6.56x56 F424
TM7
7x30 7.35x34 W437
7x33 7.38x37 Q440
7x34 7.39x38 M441
7x37 7.42x41 E444
7x38 7.43x42 M445
7x41 7.46x45 N448