Structure information

C5a1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7Y65

SPECIES

Homo sapiens

RESOLUTION

3.200

PREFERRED CHAIN

D

REFERENCE

10.1038/S41422-023-00779-2

PUBLICATION DATE

March 1, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
C5a L92 2.60x60 TM2 hydrophobic
C5a I116 3.32x32 TM3 hydrophobic
C5a V176 ECL2 hydrophobic
C5a L187 ECL2 hydrophobic
C5a C188 45.50x50 ECL2 Van der Waals
C5a C188 45.50x50 ECL2 polar (hydrogen bond with backbone)
C5a G189 45.51x51 ECL2 Van der Waals
C5a V190 45.52x52 ECL2 Van der Waals
C5a V190 45.52x52 ECL2 polar (hydrogen bond with backbone)
C5a D191 ECL2 polar (charge-assisted hydrogen bond)
C5a E199 5.35x36 TM5 polar (charge-assisted hydrogen bond)
C5a Y258 6.51x51 TM6 polar (hydrogen bond)
C5a P270 ECL3 hydrophobic
C5a F275 7.28x27 TM7 hydrophobic
C5a F275 7.28x27 TM7 Van der Waals
C5a K279 7.32x31 TM7 polar (charge-assisted hydrogen bond)
C5a D282 7.35x34 TM7 polar (charge-assisted hydrogen bond)
C5a V286 7.39x38 TM7 Van der Waals
C5a V286 7.39x38 TM7 hydrophobic

Ligands

C5a

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Residue Diagrams

A N G L V G V L F V V A F I V L A L I D 1 L N L A V A D F L S C L A L P I L F T S 2 T A L L L I S A Y M N L L I L S P L I S 3 A W I A C A V A W G L A L L L T I P S 4 Y C I T L T L L P W L F G L V L R V I A V 5 V A V V A S F F I F W L P Y Q V T G I M 6 I P N I C C N I Y A F S V C L S D L K 7
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ICL1 A K R ICL1ECL1 H H W P F ECL1ICL2 P I W C Q N F R ICL2ECL2 V V R E E Y F P P K V L C G V D Y S H ECL2ICL3 R A T R S ICL3ECL3 E P S ECL3N-term M D S F N Y T T P D Y G H Y D D K D T L D L N T P V D K T S N T L N-termC-term Q G F Q G R L R K S L P S L L R N V L T E E S V V R E S K S F T R S T V D T M A Q K T Q A V C-term R V P D I L A L V I F A V V F L V G V L G N A L V V W V T A F E T I N A I W F L N L A V A D F L S C L A L P I L F T S I V Q H G G A A C S I L P S L I L L N M Y A S I L L L A T I S A D R F L L V F K G A G L A W I A C A V A W G L A L L L T I P S F L Y R D K R R E R A V A I V R L V L G F L W P L L T L T I C Y T F I L L R T W S R T K T L K V V V A V V A S F F I F W L P Y Q V T G I M M S F L S P T F L L L K K L D S L C V S F A Y I N C C I N P I I Y V V A G
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Residue Table


GPCRdb(A)
GPCRdb(A)
C5a1 receptor
TM2
2x60 2.60x60 L92
TM3
3x32 3.32x32 I116
ECL2
45x50 45.50x50 C188
45x51 45.51x51 G189
45x52 45.52x52 V190
TM5
5x36 5.35x36 E199
TM6
6x51 6.51x51 Y258
TM7
7x27 7.28x27 F275
7x31 7.32x31 K279
7x34 7.35x34 D282
7x38 7.39x38 V286