PDB
7YAC
Resolution
3.2 Å
Released
April 19, 2023
Receptor
SST2
Class
A
Species
Homo sapiens
Ligand
paltusotine
Function
Agonist
Reference
10.1038/S41467-023-36673-Z

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Ligand Amino Acid Generic Number Segment Interaction Type
paltusotine L99 2.60x60 TM2 hydrophobic
paltusotine D122 3.32x32 TM3 polar (charge-assisted hydrogen bond)
paltusotine Q126 3.36x36 TM3 polar (hydrogen bond)
paltusotine C193 45.50x50 ECL2 Van der Waals
paltusotine T194 45.51x51 ECL2 Van der Waals
paltusotine I195 45.52x52 ECL2 hydrophobic
paltusotine I195 45.52x52 ECL2 Van der Waals
paltusotine F272 6.51x51 TM6 hydrophobic
paltusotine F272 6.51x51 TM6 Van der Waals
paltusotine Y302 7.43x42 TM7 polar (hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 A K M K ICL1ECL1 V H W P F ECL1ICL2 P I K S A K W R ICL2ECL2 G L R S N Q W G R S S C T I N W P G E ECL2ICL3 G I R V G ICL3ECL3 A I S P ECL3N-term M D M A D E P L N G S H T W L S I P F D L N G S V V S T N T S N Q T E P Y Y D N-termC-term L V K V S G T D D G E R S D S K Q D K S R L N E T T E T Q R T L L N G D L Q T S I C-term L T S N A V L T F I Y F V V C I I G L C G N T L V I Y V I L R Y T I T N I Y I L N L A I A D E L F M L G L P F L A M Q V A L G K A I C R V V M T V D G I N Q F T S I F C L T V M S I D R Y L A V V H R P R T A K M I T M A V W G V S L L V I L P I M I Y A S G A W Y T G F I I Y T F I L G F L V P L T I I C L C Y L F I I I K V K S S S S K R K K S E K K V T R M V S I V V A V F I F C W L P F Y I F N V S S V S M T P A L K G M F D F V V V L T Y A N S C A N P I L Y A F L S D N F Q N F K K S V L C
Helix box plot — Download: PNG | SVG T N G C L G I I C V V F Y I F T L V A N 1 L N L A I A D E L F M L G L P F L A M Q 2 V T L C F I S T F Q N I G D V T M V V R 3 A K M I T M A V W G V S L L V I L P I 4 Y C L C I I T L P V L F G L I F T Y I I F 5 S I V V A V F I F C W L P F Y I F N V S 6 I P N A C S N A Y T L V V V F D F M G 7

GPCRdb(A)
GPCRdb(A)
SST2 receptor
TM2
2x60 2.60x60 L99
TM3
3x32 3.32x32 D122
3x36 3.36x36 Q126
ECL2
45x50 45.50x50 C193
45x51 45.51x51 T194
45x52 45.52x52 I195
TM6
6x51 6.51x51 F272
TM7
7x42 7.43x42 Y302