Structure information

κ receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7YIT

SPECIES

Homo sapiens

RESOLUTION

3.300

PREFERRED CHAIN

A

REFERENCE

10.1038/S41467-023-37041-7

PUBLICATION DATE

April 12, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
nalfurafine L135 3.29x29 TM3 hydrophobic
nalfurafine D138 3.32x32 TM3 polar (charge-assisted hydrogen bond)
nalfurafine Y139 3.33x33 TM3 polar (hydrogen bond)
nalfurafine Y139 3.33x33 TM3 Van der Waals
nalfurafine Y139 3.33x33 TM3 aromatic (edge-to-face)
nalfurafine M142 3.36x36 TM3 Van der Waals
nalfurafine M142 3.36x36 TM3 hydrophobic
nalfurafine C210 45.50x50 ECL2 Van der Waals
nalfurafine S211 45.51x51 ECL2 Van der Waals
nalfurafine K227 5.39x40 TM5 Van der Waals
nalfurafine V230 5.42x43 TM5 Van der Waals
nalfurafine V230 5.42x43 TM5 hydrophobic
nalfurafine W287 6.48x48 TM6 Van der Waals
nalfurafine W287 6.48x48 TM6 hydrophobic
nalfurafine I290 6.51x51 TM6 hydrophobic
nalfurafine I290 6.51x51 TM6 Van der Waals
nalfurafine H291 6.52x52 TM6 Van der Waals
nalfurafine H291 6.52x52 TM6 aromatic (face-to-edge)
nalfurafine I294 6.55x55 TM6 hydrophobic
nalfurafine I294 6.55x55 TM6 Van der Waals
nalfurafine Y312 7.35x34 TM7 Van der Waals
nalfurafine I316 7.39x38 TM7 Van der Waals
nalfurafine I316 7.39x38 TM7 hydrophobic
nalfurafine G319 7.42x41 TM7 Van der Waals
nalfurafine Y320 7.43x42 TM7 Van der Waals
nalfurafine Y320 7.43x42 TM7 hydrophobic

Ligands

nalfurafine

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Residue Diagrams

S N G V L G V V F V V S Y V A T I I V P 1 F N L A L A D A L V T T T M P F Q S T V 2 M T L T F I S T F M N Y Y D I S I V I K 3 A K I I N I C I W L L S S S V G I S A I 4 Y C V I I I L V P I V F A F I F V C I K M 5 L V V V A V F V V C W T P I H I F I L V 6 I P N L S S N T Y G L A I C F Y Y S S 7
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ICL1 T K M K ICL1ECL1 S W P F ECL1ICL2 P V K A L D F R ICL2ECL2 G T K V R E D V D V I E C S L Q F P D D ECL2ICL3 R L L S G ICL3ECL3 S T S H ECL3N-term M D S P I Q I F R G E P G P T C A P S A C L P P N S S A W F P G W A E P D S N G S A G S E D A Q L E P A H I S P N-termC-term P L K M R M E R Q S T S R V R N T V Q D P A Y L R D I D G M N K P V C-term A I P V I I T A V Y S V V F V V G L V G N S L V M F V I I R Y T A T N I Y I F N L A L A D A L V T T T M P F Q S T V Y L M N G D V L C K I V I S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H T P L K A K I I N I C I W L L S S S V G I S A I V L G D Y S W W D L F M K I C V F I F A F V I P V L I I I V C Y T L M I L R L K S V S R E K D R N L R R I T R L V L V V V A V F V V C W T P I H I F I L V E A L G S T A A L S S Y Y F C I A L G Y T N S S L N P I L Y A F L D E N F R D F K R C F C F
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Residue Table


GPCRdb(A)
GPCRdb(A)
κ receptor
TM3
3x29 3.29x29 I135
3x32 3.32x32 D138
3x33 3.33x33 Y139
3x36 3.36x36 M142
ECL2
45x50 45.50x50 C210
45x51 45.51x51 S211
TM5
5x40 5.39x40 K227
5x43 5.42x43 V230
TM6
6x48 6.48x48 W287
6x51 6.51x51 I290
6x52 6.52x52 H291
6x55 6.55x55 I294
TM7
7x34 7.35x34 Y312
7x38 7.39x38 I316
7x41 7.42x41 G319
7x42 7.43x42 Y320