Structure information

α1A-adrenoceptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7YM8

SPECIES

Homo sapiens

RESOLUTION

2.920

PREFERRED CHAIN

A

REFERENCE

10.1038/S41467-023-39310-X

PUBLICATION DATE

July 5, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
oxymetazoline D106 3.32x32 TM3 polar (charge-assisted hydrogen bond)
oxymetazoline V107 3.33x33 TM3 hydrophobic
oxymetazoline V107 3.33x33 TM3 Van der Waals
oxymetazoline C110 3.36x36 TM3 polar (hydrogen bond)
oxymetazoline Y184 5.38x39 TM5 Van der Waals
oxymetazoline Y184 5.38x39 TM5 hydrophobic
oxymetazoline W285 6.48x48 TM6 Van der Waals
oxymetazoline W285 6.48x48 TM6 hydrophobic
oxymetazoline F288 6.51x51 TM6 Van der Waals
oxymetazoline F288 6.51x51 TM6 aromatic (edge-to-face)
oxymetazoline F289 6.52x52 TM6 Van der Waals
oxymetazoline F289 6.52x52 TM6 hydrophobic
oxymetazoline F312 7.39x38 TM7 hydrophobic
oxymetazoline F312 7.39x38 TM7 Van der Waals
oxymetazoline Y316 7.43x42 TM7 Van der Waals
oxymetazoline Y316 7.43x42 TM7 hydrophobic

Ligands

oxymetazoline

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Residue Diagrams

I N G L V G F L I L G G L I V G L L I A 1 V N L A V A D L L L T T S V L P F S A I F 2 I C L G M I S A T C C L V D V A A W I N 3 G L M A L L C V W A L S L V I S I G P L 4 Y M V L I I A L P L Y F S G L A S F L V Y 5 G I V V G C F V L C W L P F F L V M P I 6 I P N I C S N L Y G L W F V I K F V T 7
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ICL1 R H L H ICL1ECL1 Y W A F ECL1ICL2 P L R Y P T I V ICL2ECL2 R Q P A P E D E T I C Q I N E ECL2ICL3 K T D K S D S E Q V T L R I H R K N A P A G G S G M A S A K T K T H F S V R ICL3ECL3 P D F K P ECL3N-term M V F L S G N A S D S S N C T Q P P A N-termC-term I Q C L C R K Q S S K H A L G Y T L H P P S Q A V E G Q H K D M V R I P V G S R E T F Y R I S K T D G V C E W K F F S S M P R G S A R I T V S K D Q S S C T T A R V R S K S F L Q V C C C V G P S T P S L D K N H Q V P T I K V H T I S L S E N G E E V C-term P V N I S K A I L L G V I L G G L I L F G V L G N I L V I L S V A C H S V T H Y Y I V N L A V A D L L L T S T V L P F S A I F E V L G G R V F C N I W A A V D V L C C T A S I M G L C I I S I D R Y I G V S Y T Q R R G L M A L L C V W A L S L V I S I G P L F G W E P G Y V L F S A L G S F Y L P L A I I L V M Y C R V Y V V A K R E S R G L K S G L L L K F S R E K K A A K T L G I V V G C F V L C W L P F F L V M P I G S F F S E T V F K I V F W L G Y L N S C I N P I I Y P C S S Q E F Q N F K K A V L R
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Residue Table


GPCRdb(A)
GPCRdb(A)
α1A-adrenoceptor
TM3
3x32 3.32x32 D106
3x33 3.33x33 V107
3x36 3.36x36 C110
TM5
5x39 5.38x39 Y184
TM6
6x48 6.48x48 W285
6x51 6.51x51 F288
6x52 6.52x52 F289
TM7
7x38 7.39x38 F312
7x42 7.43x42 Y316