PDB
7YMH
Resolution
3.5 Å
Released
July 5, 2023
Receptor
α1A
Class
A
Species
Homo sapiens
Ligands
Function
Nb29
PAM
(-)-noradrenaline
Agonist
Reference
10.1038/S41467-023-39310-X
Nb29 (-)-noradrenaline

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
Nb29 F86 2.64x63 TM2 hydrophobic
Nb29 L89 2.67x66 TM2 Van der Waals
Nb29 G90 2.68x67 TM2 Van der Waals
Nb29 Y91 23.49x49 ECL1 hydrophobic
(-)-noradrenaline D106 3.32x32 TM3 polar (hydrogen bond)
(-)-noradrenaline D106 3.32x32 TM3 polar (charge-charge)
(-)-noradrenaline V107 3.33x33 TM3 hydrophobic
(-)-noradrenaline C110 3.36x36 TM3 Van der Waals
Nb29 R166 ECL2 polar (hydrogen bond)
Nb29 R166 ECL2 polar (charge-charge)
Nb29 A169 ECL2 polar (hydrogen bond with backbone)
Nb29 P170 ECL2 hydrophobic
Nb29 E171 ECL2 polar (hydrogen bond)
Nb29 E171 ECL2 polar (charge-charge)
Nb29 D172 ECL2 polar (charge-charge)
Nb29 D172 ECL2 polar (hydrogen bond)
Nb29 T174 ECL2 hydrophobic
Nb29 T174 ECL2 polar (hydrogen bond)
Nb29 I175 ECL2 hydrophobic
Nb29 C176 45.50x50 ECL2 polar (hydrogen bond with backbone)
Nb29 Q177 45.51x51 ECL2 Van der Waals
Nb29 I178 45.52x52 ECL2 polar (hydrogen bond with backbone)
(-)-noradrenaline I178 45.52x52 ECL2 Van der Waals
Nb29 E180 ECL2 hydrophobic
Nb29 E180 ECL2 polar (charge-charge)
(-)-noradrenaline S188 5.42x43 TM5 Van der Waals
(-)-noradrenaline W285 6.48x48 TM6 Van der Waals
(-)-noradrenaline F288 6.51x51 TM6 aromatic (pi-cation)
(-)-noradrenaline F288 6.51x51 TM6 hydrophobic
(-)-noradrenaline F288 6.51x51 TM6 aromatic (edge-to-face)
(-)-noradrenaline F289 6.52x52 TM6 hydrophobic
(-)-noradrenaline M292 6.55x55 TM6 Van der Waals
Nb29 E305 7.32x31 TM7 Van der Waals
Nb29 F308 7.35x34 TM7 hydrophobic
Nb29 F308 7.35x34 TM7 aromatic (pi-cation)
Nb29 K309 7.36x35 TM7 aromatic (pi-cation)
(-)-noradrenaline F312 7.39x38 TM7 aromatic (pi-cation)
(-)-noradrenaline Y316 7.43x42 TM7 aromatic (pi-cation)

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 R H L H ICL1ECL1 Y W A F ECL1ICL2 P L R Y P T I V ICL2ECL2 R Q P A P E D E T I C Q I N E ECL2ICL3 K T D K S D S E Q V T L R I H R K N A P A G G S G M A S A K T K T H F S V R ICL3ECL3 P D F K P ECL3N-term M V F L S G N A S D S S N C T Q P P A N-termC-term I Q C L C R K Q S S K H A L G Y T L H P P S Q A V E G Q H K D M V R I P V G S R E T F Y R I S K T D G V C E W K F F S S M P R G S A R I T V S K D Q S S C T T A R V R S K S F L Q V C C C V G P S T P S L D K N H Q V P T I K V H T I S L S E N G E E V C-term P V N I S K A I L L G V I L G G L I L F G V L G N I L V I L S V A C H S V T H Y Y I V N L A V A D L L L T S T V L P F S A I F E V L G G R V F C N I W A A V D V L C C T A S I M G L C I I S I D R Y I G V S Y T Q R R G L M A L L C V W A L S L V I S I G P L F G W E P G Y V L F S A L G S F Y L P L A I I L V M Y C R V Y V V A K R E S R G L K S G L L L K F S R E K K A A K T L G I V V G C F V L C W L P F F L V M P I G S F F S E T V F K I V F W L G Y L N S C I N P I I Y P C S S Q E F Q N F K K A V L R
Helix box plot — Download: PNG | SVG I N G L V G F L I L G G L I V G L L I A 1 V N L A V A D L L L T T S V L P F S A I F 2 I C L G M I S A T C C L V D V A A W I N 3 G L M A L L C V W A L S L V I S I G P L 4 Y M V L I I A L P L Y F S G L A S F L V Y 5 G I V V G C F V L C W L P F F L V M P I 6 I P N I C S N L Y G L W F V I K F V T 7

GPCRdb(A)
GPCRdb(A)
α1A-adrenoceptor
TM2
2x63 2.64x63 F86
2x66 2.67x66 L89
2x67 2.68x67 G90
ECL1
23x49 23.49x49 Y91
TM3
3x32 3.32x32 D106
3x33 3.33x33 V107
3x36 3.36x36 C110
ECL2
45x50 45.50x50 C176
45x51 45.51x51 Q177
45x52 45.52x52 I178
TM5
5x43 5.42x43 S188
TM6
6x48 6.48x48 W285
6x51 6.51x51 F288
6x52 6.52x52 F289
6x55 6.55x55 M292
TM7
7x31 7.32x31 E305
7x34 7.35x34 F308
7x35 7.36x35 K309
7x38 7.39x38 F312
7x42 7.43x42 Y316