Structure information

Y2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7YOO

SPECIES

Homo sapiens

RESOLUTION

3.110

PREFERRED CHAIN

R

REFERENCE

10.1016/J.STR.2022.11.010

PUBLICATION DATE

March 22, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
neuropeptide Y L40 N-term hydrophobic
neuropeptide Y T107 2.61x60 TM2 polar (hydrogen bond)
neuropeptide Y Y110 2.64x63 TM2 hydrophobic
neuropeptide Y Y110 2.64x63 TM2 Van der Waals
neuropeptide Y T111 2.65x64 TM2 Van der Waals
neuropeptide Y T111 2.65x64 TM2 polar (hydrogen bond)
neuropeptide Y Q130 3.32x32 TM3 polar (hydrogen bond)
neuropeptide Y V134 3.36x36 TM3 hydrophobic
neuropeptide Y L183 4.60x61 TM4 hydrophobic
neuropeptide Y E188 ECL2 Van der Waals
neuropeptide Y I192 ECL2 Van der Waals
neuropeptide Y I192 ECL2 hydrophobic
neuropeptide Y E193 ECL2 polar (charge-assisted hydrogen bond)
neuropeptide Y I194 ECL2 hydrophobic
neuropeptide Y I194 ECL2 Van der Waals
neuropeptide Y I200 ECL2 Van der Waals
neuropeptide Y T204 45.51x51 ECL2 Van der Waals
neuropeptide Y E205 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
neuropeptide Y E211 ECL2 Van der Waals
neuropeptide Y Y219 5.38x39 TM5 Van der Waals
neuropeptide Y Y219 5.38x39 TM5 hydrophobic
neuropeptide Y S220 5.39x40 TM5 Van der Waals
neuropeptide Y S220 5.39x40 TM5 polar (hydrogen bond)
neuropeptide Y Q288 6.55x55 TM6 polar (hydrogen bond)
neuropeptide Y D292 6.59x59 TM6 Van der Waals
neuropeptide Y S295 ECL3 Van der Waals
neuropeptide Y L298 ECL3 Van der Waals
neuropeptide Y L298 ECL3 polar (hydrogen bond with backbone)
neuropeptide Y D299 ECL3 Van der Waals
neuropeptide Y D299 ECL3 polar (hydrogen bond with backbone)
neuropeptide Y L300 ECL3 Van der Waals
neuropeptide Y K301 ECL3 Van der Waals
neuropeptide Y Y303 7.31x30 TM7 Van der Waals
neuropeptide Y Y303 7.31x30 TM7 hydrophobic
neuropeptide Y F307 7.35x34 TM7 Van der Waals
neuropeptide Y H311 7.39x38 TM7 polar (hydrogen bond)

Ligands

neuropeptide Y

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Residue Diagrams

S N G I V G L L I I S C Y A L I L V V Q 1 A N L A V A D L L V N L T C L P F T L T Y 2 V T L T I T S V Q V A L G Q A Y P V L H 3 S F L I I G L A W G I S A L L A S P L 4 Y S F S I I G L P L V Y L I L L S S L S Y 5 V C V V V V F A V S W L P L H A F Q L A 6 L P N A F T S C M A I I H F V T F I L 7
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ICL1 K S M R ICL1ECL1 E W K M ECL1ICL2 H L E S K I ICL2ECL2 E Y S L I E I I P D F E I V A C T E K W P G E E K ECL2ICL3 A A ICL3ECL3 S Q V L ECL3N-term M G P I G A E A D E N Q T V E E M K V E Q Y G P Q T T P R G E L V P D P E P E L I D S T K L I N-termC-term L D A I H S E V S V T F K A K K N L E V R K N S G P N D S F T E A T N V C-term E V Q V V L I L A Y C S I I L L G V I G N S L V I H V V I K F T V T N F F I A N L A V A D L L V N T L C L P F T L T Y T L M G G P V L C H L V P Y A Q G L A V Q V S T I T L T V I A L D R H R C I V Y S K R I S F L I I G L A W G I S A L L A S P L A I F R S I Y G T V Y S L S S L L I L Y V L P L G I I S F S Y T R I W S K L K N H V S P G N D H Y H Q R R Q K T T K M L V C V V V V F A V S W L P L H A F Q L A V D I D D L K E Y K L I F T V F H I I A M C S T F A N P L L Y G W M N S N F L S E Q R Y R K A A F R C
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Residue Table


GPCRdb(A)
GPCRdb(A)
Y2 receptor
TM2
2x60 2.61x60 T107
2x63 2.64x63 Y110
2x64 2.65x64 T111
TM3
3x32 3.32x32 Q130
3x36 3.36x36 V134
TM4
4x61 4.60x61 L183
ECL2
45x51 45.51x51 T204
45x52 45.52x52 E205
TM5
5x39 5.38x39 Y219
5x40 5.39x40 S220
TM6
6x55 6.55x55 Q288
6x59 6.59x59 D292
TM7
7x30 7.31x30 Y303
7x34 7.35x34 F307
7x38 7.39x38 H311