PDB
8DPH
Resolution
3.2 Å
Released
Aug. 24, 2022
Receptor
5-HT2C
Class
A
Species
Homo sapiens
Ligand
lorcaserin
Function
Agonist
Reference
10.1016/J.CELREP.2022.111211

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Ligand Amino Acid Generic Number Segment Interaction Type
lorcaserin D134 3.32x32 TM3 polar (charge-assisted hydrogen bond)
lorcaserin D134 3.32x32 TM3 polar (hydrogen bond with backbone)
lorcaserin V135 3.33x33 TM3 polar (hydrogen bond with backbone)
lorcaserin V135 3.33x33 TM3 Van der Waals
lorcaserin S138 3.36x36 TM3 polar (hydrogen bond)
lorcaserin W324 6.48x48 TM6 Van der Waals
lorcaserin F327 6.51x51 TM6 hydrophobic
lorcaserin F327 6.51x51 TM6 Van der Waals
lorcaserin V354 7.39x38 TM7 Van der Waals
lorcaserin Y358 7.43x42 TM7 polar (hydrogen bond)

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ICL1 K K L H ICL1ECL1 Y V W P L ECL1ICL2 P I E H S R F N ICL2ECL2 E E K V F V N N T T C V L N ECL2ICL3 G H T E E P P G L S L D F L K C C K R N T A E E E N S A N P N Q D Q N A R R R K K K E R R P R G T ICL3ECL3 E K S C ECL3N-term M V N L R N A V H S F L V H L I G L L V W Q S D I S V S P V A A I V T D I F N T S D G G R F K F P D G V Q N-termC-term N Y K V E K K P P V R Q I P R V A A T A L S G R E L N V N I Y R H T N E P V I E K A S D N E P G I E M Q V E N L E L P V N P S S V V S E R I S S V C-term N W P A L S I V I I I I M T I G G N I L V I M A V S M E N A T N Y F L M S L A I A D M L V G L L V M P L S L L A I L Y D P R Y L C P V W I S L D V L F S T A S I M H L C A I S L D R Y V A I R N S R T K A I M K I A I V W A I S I G V S V P I P V I G L R D D P N F V L I G S F V A F F I P L T I M V I T Y C L T I Y V L R R Q A L M L L H M Q A I N N E R K A S K V L G I V F F V F L I M W C P F F I T N I L S V L C N Q K L M E K L L N V F V W I G Y V C S G I N P L V Y T L F N K I F S N Y R R A Y L R C
Helix box plot — Download: PNG | SVG I N G G I T M I I I I V I S L A P W N 1 M S L A I A D M L V G L L V M P L S L L A 2 A C L H M I S A T S F L V D L S I W V P 3 A I M K I A I V W A I S I G V S V P I 4 Y T I V M I T L P I F F A V F S G I L V F 5 G I V F F V F L I M W C P F F I T N I L 6 L P N I G S C V Y G I W V F V N L L K 7

GPCRdb(A)
GPCRdb(A)
5-HT2C receptor
TM3
3x32 3.32x32 D134
3x33 3.33x33 V135
3x36 3.36x36 S138
TM6
6x48 6.48x48 W324
6x51 6.51x51 F327
TM7
7x38 7.39x38 V354
7x42 7.43x42 Y358