Structure information

5-HT2C receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8DPI

SPECIES

Homo sapiens

RESOLUTION

3.400

PREFERRED CHAIN

A

REFERENCE

10.1016/J.CELREP.2022.111211

PUBLICATION DATE

Aug. 24, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
lorcaserin D134 3.32x32 TM3 polar (charge-assisted hydrogen bond)
lorcaserin D134 3.32x32 TM3 polar (hydrogen bond with backbone)
lorcaserin V135 3.33x33 TM3 hydrophobic
lorcaserin V135 3.33x33 TM3 Van der Waals
lorcaserin S138 3.36x36 TM3 polar (hydrogen bond)
lorcaserin G218 5.42x43 TM5 Van der Waals
lorcaserin S219 5.43x44 TM5 Van der Waals
lorcaserin A222 5.46x461 TM5 hydrophobic
lorcaserin A222 5.46x461 TM5 Van der Waals
lorcaserin F327 6.51x51 TM6 Van der Waals
lorcaserin F327 6.51x51 TM6 hydrophobic
lorcaserin F328 6.52x52 TM6 aromatic (edge-to-face)
lorcaserin F328 6.52x52 TM6 Van der Waals
lorcaserin V354 7.39x38 TM7 Van der Waals
lorcaserin Y358 7.43x42 TM7 Van der Waals

Ligands

lorcaserin

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Residue Diagrams

I N G G I T M I I I I V I S L A P W N 1 M S L A I A D M L V G L L V M P L S L L A 2 A C L H M I S A T S F L V D L S I W V P 3 A I M K I A I V W A I S I G V S V P I 4 Y T I V M I T L P I F F A V F S G I L V F 5 G I V F F V F L I M W C P F F I T N I L 6 L P N I G S C V Y G I W V F V N L L K 7
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ICL1 K K L H ICL1ECL1 Y V W P L ECL1ICL2 P I E H S R F N ICL2ECL2 E E K V F V N N T T C V L N ECL2ICL3 G H T E E P P G L S L D F L K C C K R N T A E E E N S A N P N Q D Q N A R R R K K K E R R P R G T ICL3ECL3 E K S C ECL3N-term M V N L R N A V H S F L V H L I G L L V W Q S D I S V S P V A A I V T D I F N T S D G G R F K F P D G V Q N-termC-term N Y K V E K K P P V R Q I P R V A A T A L S G R E L N V N I Y R H T N E P V I E K A S D N E P G I E M Q V E N L E L P V N P S S V V S E R I S S V C-term N W P A L S I V I I I I M T I G G N I L V I M A V S M E N A T N Y F L M S L A I A D M L V G L L V M P L S L L A I L Y D P R Y L C P V W I S L D V L F S T A S I M H L C A I S L D R Y V A I R N S R T K A I M K I A I V W A I S I G V S V P I P V I G L R D D P N F V L I G S F V A F F I P L T I M V I T Y C L T I Y V L R R Q A L M L L H M Q A I N N E R K A S K V L G I V F F V F L I M W C P F F I T N I L S V L C N Q K L M E K L L N V F V W I G Y V C S G I N P L V Y T L F N K I F S N Y R R A Y L R C
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT2C receptor
TM3
3x32 3.32x32 D134
3x33 3.33x33 V135
3x36 3.36x36 S138
TM5
5x43 5.42x43 G218
5x44 5.43x44 S219
5x461 5.46x461 A222
TM6
6x51 6.51x51 F327
6x52 6.52x52 F328
TM7
7x38 7.39x38 V354
7x42 7.43x42 Y358