PDB
8EF6
Resolution
3.2 Å
Released
Nov. 9, 2022
Receptor
μ
Class
A
Species
Homo sapiens
Ligand
Function
morphine
Agonist
Reference
10.1016/J.CELL.2022.09.041

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Ligand Amino Acid Generic Number Segment Interaction Type
morphine D149 3.32x32 TM3 polar (charge-charge)
morphine Y150 3.33x33 TM3 hydrophobic
morphine Y150 3.33x33 TM3 aromatic (pi-cation)
morphine M153 3.36x36 TM3 hydrophobic
morphine V238 5.42x43 TM5 hydrophobic
morphine W295 6.48x48 TM6 Van der Waals
morphine I298 6.51x51 TM6 hydrophobic
morphine H299 6.52x52 TM6 aromatic (edge-to-face)
morphine V302 6.55x55 TM6 Van der Waals
morphine W320 7.35x34 TM7 hydrophobic
morphine I324 7.39x38 TM7 hydrophobic
morphine Y328 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A A P T N A S N C T D A L A Y S S C S P A P S P G S W V N L S H L D G N L S D P C G P N R T D L G G R D S L C P P T G S P S N-termC-term P T S S N I E Q Q N S T R I R Q N T R D H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M I T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G T I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I I N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L V T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Helix box plot — Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I I N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7

GPCRdb(A)
GPCRdb(A)
μ receptor
TM3
3x32 3.32x32 D149
3x33 3.33x33 Y150
3x36 3.36x36 M153
TM5
5x43 5.42x43 V238
TM6
6x48 6.48x48 W295
6x51 6.51x51 I298
6x52 6.52x52 H299
6x55 6.55x55 V302
TM7
7x34 7.35x34 W320
7x38 7.39x38 I324
7x42 7.43x42 Y328