PDB
8EFB
Resolution
3.2 Å
Released
Nov. 9, 2022
Receptor
μ
Class
A
Species
Homo sapiens
Ligand
OLICERIDINE
Function
Agonist (partial)
Reference
10.1016/J.CELL.2022.09.041

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Ligand Amino Acid Generic Number Segment Interaction Type
OLICERIDINE Q126 2.60x60 TM2 polar (hydrogen bond)
OLICERIDINE N129 2.63x63 TM2 Van der Waals
OLICERIDINE I146 3.29x29 TM3 hydrophobic
OLICERIDINE I146 3.29x29 TM3 Van der Waals
OLICERIDINE D149 3.32x32 TM3 polar (charge-assisted hydrogen bond)
OLICERIDINE Y150 3.33x33 TM3 hydrophobic
OLICERIDINE Y150 3.33x33 TM3 Van der Waals
OLICERIDINE M153 3.36x36 TM3 polar (hydrogen bond)
OLICERIDINE C219 45.50x50 ECL2 Van der Waals
OLICERIDINE C219 45.50x50 ECL2 hydrophobic
OLICERIDINE W295 6.48x48 TM6 Van der Waals
OLICERIDINE W295 6.48x48 TM6 aromatic (edge-to-face)
OLICERIDINE I298 6.51x51 TM6 hydrophobic
OLICERIDINE I298 6.51x51 TM6 Van der Waals
OLICERIDINE H299 6.52x52 TM6 Van der Waals
OLICERIDINE I324 7.39x38 TM7 hydrophobic
OLICERIDINE I324 7.39x38 TM7 Van der Waals
OLICERIDINE G327 7.42x41 TM7 Van der Waals
OLICERIDINE Y328 7.43x42 TM7 Van der Waals
OLICERIDINE Y328 7.43x42 TM7 hydrophobic

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ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A A P T N A S N C T D A L A Y S S C S P A P S P G S W V N L S H L D G N L S D P C G P N R T D L G G R D S L C P P T G S P S N-termC-term P T S S N I E Q Q N S T R I R Q N T R D H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M I T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G T I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I I N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L V T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Helix box plot — Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I I N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7

GPCRdb(A)
GPCRdb(A)
μ receptor
TM2
2x60 2.60x60 Q126
2x63 2.63x63 N129
TM3
3x29 3.29x29 I146
3x32 3.32x32 D149
3x33 3.33x33 Y150
3x36 3.36x36 M153
ECL2
45x50 45.50x50 C219
TM6
6x48 6.48x48 W295
6x51 6.51x51 I298
6x52 6.52x52 H299
TM7
7x38 7.39x38 I324
7x41 7.42x41 G327
7x42 7.43x42 Y328