Structure information

μ receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8F7Q

SPECIES

Homo sapiens

RESOLUTION

3.220

PREFERRED CHAIN

R

REFERENCE

10.1016/J.CELL.2022.12.026

PUBLICATION DATE

Dec. 14, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
β-endorphin L131 2.65x65 TM2 hydrophobic
β-endorphin I146 3.29x29 TM3 hydrophobic
β-endorphin Y150 3.33x33 TM3 hydrophobic
β-endorphin Q214 ECL2 polar (hydrogen bond)
β-endorphin Q214 ECL2 Van der Waals
β-endorphin D218 ECL2 polar (charge-assisted hydrogen bond)
β-endorphin C219 45.50x50 ECL2 Van der Waals
β-endorphin T220 45.51x51 ECL2 Van der Waals
β-endorphin V238 5.42x43 TM5 Van der Waals
β-endorphin V302 6.55x55 TM6 hydrophobic
β-endorphin W320 7.35x34 TM7 Van der Waals
β-endorphin W320 7.35x34 TM7 polar (hydrogen bond)
β-endorphin I324 7.39x38 TM7 hydrophobic
β-endorphin I324 7.39x38 TM7 Van der Waals
β-endorphin Y328 7.43x42 TM7 Van der Waals

Ligands

β-endorphin

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Residue Diagrams

F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I I N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7
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ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A A P T N A S N C T D A L A Y S S C S P A P S P G S W V N L S H L D G N L S D P C G P N R T D L G G R D S L C P P T G S P S N-termC-term P T S S N I E Q Q N S T R I R Q N T R D H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M I T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G T I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I I N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L V T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
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Residue Table


GPCRdb(A)
GPCRdb(A)
μ receptor
TM2
2x65 2.65x65 L131
TM3
3x29 3.29x29 I146
3x33 3.33x33 Y150
ECL2
45x50 45.50x50 C219
45x51 45.51x51 T220
TM5
5x43 5.42x43 V238
TM6
6x55 6.55x55 V302
TM7
7x34 7.35x34 W320
7x38 7.39x38 I324
7x42 7.43x42 Y328