PDB
8F7X
Resolution
3.3 Å
Released
Dec. 14, 2022
Receptor
NOP
Class
A
Species
Homo sapiens
Ligand
nociceptin/orphanin FQ (Human)
Function
Agonist
Reference
10.1016/J.CELL.2022.12.026

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Ligand Amino Acid Generic Number Segment Interaction Type
nociceptin/orphanin FQ (Human) G114 2.67x67 TM2 Van der Waals
nociceptin/orphanin FQ (Human) G114 2.67x67 TM2 polar (hydrogen bond with backbone)
nociceptin/orphanin FQ (Human) V126 3.28x28 TM3 Van der Waals
nociceptin/orphanin FQ (Human) I127 3.29x29 TM3 hydrophobic
nociceptin/orphanin FQ (Human) D130 3.32x32 TM3 polar (charge-assisted hydrogen bond)
nociceptin/orphanin FQ (Human) Y131 3.33x33 TM3 Van der Waals
nociceptin/orphanin FQ (Human) Y131 3.33x33 TM3 aromatic (face-to-edge)
nociceptin/orphanin FQ (Human) M134 3.36x36 TM3 Van der Waals
nociceptin/orphanin FQ (Human) M134 3.36x36 TM3 hydrophobic
nociceptin/orphanin FQ (Human) E194 ECL2 polar (charge-assisted hydrogen bond)
nociceptin/orphanin FQ (Human) E199 ECL2 polar (charge-assisted hydrogen bond)
nociceptin/orphanin FQ (Human) C200 45.50x50 ECL2 hydrophobic
nociceptin/orphanin FQ (Human) C200 45.50x50 ECL2 Van der Waals
nociceptin/orphanin FQ (Human) L201 45.51x51 ECL2 hydrophobic
nociceptin/orphanin FQ (Human) L201 45.51x51 ECL2 Van der Waals
nociceptin/orphanin FQ (Human) I219 5.42x43 TM5 Van der Waals
nociceptin/orphanin FQ (Human) V279 6.51x51 TM6 Van der Waals
nociceptin/orphanin FQ (Human) V283 6.55x55 TM6 hydrophobic
nociceptin/orphanin FQ (Human) V283 6.55x55 TM6 Van der Waals
nociceptin/orphanin FQ (Human) Q286 6.58x58 TM6 Van der Waals
nociceptin/orphanin FQ (Human) Q291 ECL3 Van der Waals
nociceptin/orphanin FQ (Human) P292 ECL3 Van der Waals
nociceptin/orphanin FQ (Human) S293 ECL3 Van der Waals
nociceptin/orphanin FQ (Human) L301 7.35x34 TM7 Van der Waals
nociceptin/orphanin FQ (Human) Y309 7.43x42 TM7 polar (hydrogen bond)
nociceptin/orphanin FQ (Human) Y309 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 F W P F ECL1ICL2 P I R A L D V R ICL2ECL2 S A Q V E D E E I E C L V E I P T ECL2ICL3 R L L S G ICL3ECL3 V Q P S ECL3N-term M E P L F P A P F W E V I Y G S H L Q G N L S L L S P N H S L L P P H L L L N A S H G A F L P N-termC-term A S A L R R D V Q V S D R V R S I A K D V A L A C K T S E T V P R P A C-term L G L K V T I V G L Y L A V C V G G L L G N C L V M Y V I L R H T A T N I Y I F N L A L A D T L V L L T L P F Q G T D I L L G G N A L C K T V I A I D Y Y N M F T S T F T L T A M S V D R Y V A I C H T S S K A Q A V N V A I W A L A S V V G V P V A I M G P Q D Y W G P V F A I C I F L F S F I V P V L V I S V C Y S L M I R R L R G V S R E K D R N L R R I T R L V L V V V A V F V G C W T P V Q V F V L A Q G L G S E T A V A I L R F C T A L G Y V N S C L N P I L Y A F L D E N F R K F K A C F C C
Helix box plot — Download: PNG | SVG C N G L L G G V C V A L Y L G V I T V K 1 F N L A L A D T L V L L T L P F Q G T D 2 A T L T F T S T F M N Y Y D I A I V T K 3 A Q A V N V A I W A L A S V V G V P V A 4 Y C V S I V L V P V I F S F L F I C I A F 5 L V V V A V F V G C W T P V Q V F V L A 6 I P N L C S N V Y G L A T C F R L I A 7

GPCRdb(A)
GPCRdb(A)
NOP receptor
TM2
2x67 2.67x67 G114
TM3
3x28 3.28x28 V126
3x29 3.29x29 I127
3x32 3.32x32 D130
3x33 3.33x33 Y131
3x36 3.36x36 M134
ECL2
45x50 45.50x50 C200
45x51 45.51x51 L201
TM5
5x43 5.42x43 I219
TM6
6x51 6.51x51 V279
6x55 6.55x55 V283
6x58 6.58x58 Q286
TM7
7x34 7.35x34 L301
7x42 7.43x42 Y309