PDB
8G94
Resolution
3.2 Å
Released
April 19, 2023
Receptor
S1P1
Class
A
Species
Homo sapiens
Ligand
Early activation antigen CD69
Function
Allosteric agonist
Reference
10.7554/ELIFE.88204

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Ligand Amino Acid Generic Number Segment Interaction Type
Early activation antigen CD69 F161 4.43x43 TM4 hydrophobic
Early activation antigen CD69 I164 4.46x46 TM4 hydrophobic
Early activation antigen CD69 V169 4.51x51 TM4 hydrophobic
Early activation antigen CD69 I179 4.61x61 TM4 hydrophobic
Early activation antigen CD69 M180 4.62x62 TM4 hydrophobic

NGL is a WebGL based 3D viewer powered by MMTF.

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Snake plot — Download: PNG | SVG
ICL1 K K F H ICL1ECL1 G A T T Y K L ECL1ICL2 M K L H N G S ICL2ECL2 W N C I S A L S S C S T V L P L Y ECL2ICL3 F R K N I S K A ICL3ECL3 K V K T C ECL3N-term M G P T S V P L V K A H R S S V S D Y V N Y D I I V R H Y N Y T G K L N I S A D K N-termC-term C C K C P S G D S A G K F K R P I I A G M E F S R S K S D N S S H P Q K D E G D N P E T I M S S G N V N S S S C-term E N S I K L T S V V F I L I C C F I I L E N I F V L L T I W K T R P M Y Y F I G N L A L S D L L A G V A Y T A N L L L S T P A Q W F L R E G S M F V A L S A S V F S L L A I A I E R Y I T M L K N N F R L F L L I S A C W V I S L I L G G L P I M G H K H Y I L F C T T V F T L L L L S I V I L Y C R I Y S L V R T R S R R L T S R S S E K S L A L L K T V I I V L S V F I A C W A P L F I L L L L D V G C D I L F R A E Y F L V L A V L N S G T N P I I Y T L T N K E F I R M R R A I M S
Helix box plot — Download: PNG | SVG I N E L I I F C C I L I F V V S T L K I 1 G N L A L S D L L A G V A Y T A N L L L 2 A L L S F V S A S L A V F M S G E R L F 3 L F L L I S A C W V I S L I L G G L P I 4 Y L I V I S L L L L T F V T T C F L I Y 5 I I V L S V F I A C W A P L F I L L L L 6 I P N T G S N L V A L V L F Y E A R F 7

GPCRdb(A)
GPCRdb(A)
S1P1 receptor
TM4
4x43 4.43x43 F161
4x46 4.46x46 I164
4x51 4.51x51 V169
4x61 4.61x61 I179
4x62 4.62x62 M180