PDB
8GCM
Resolution
3.5 Å
Released
Jan. 3, 2024
Receptor
EP4
Class
A
Species
Homo sapiens
Ligand
Function
L902688
Agonist
Reference
10.1073/PNAS.2216329120

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Ligand Amino Acid Generic Number Segment Interaction Type
L902688 I23 N-term Van der Waals
L902688 P24 N-term hydrophobic
L902688 M27 1.42x42 TM1 hydrophobic
L902688 T69 2.54x54 TM2 Van der Waals
L902688 V72 2.57x57 TM2 Van der Waals
L902688 T76 2.61x61 TM2 Van der Waals
L902688 T79 ECL1 Van der Waals
L902688 L99 3.32x32 TM3 hydrophobic
L902688 T168 ECL2 hydrophobic
L902688 W169 ECL2 hydrophobic
L902688 I315 7.39x38 TM7 hydrophobic
L902688 S319 7.43x42 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 R K E Q K E ICL1ECL1 G Q W P G ECL1ICL2 A Y F Y S H Y V ICL2ECL2 L G S S R L Q Y P D T W C F I D W T T N ECL2ICL3 S L G T E Q H H A A A A A S V A S R G H P A A S P A L P R L S D F R R R R S F ICL3ECL3 Q P S L E R E V S K ECL3N-term M S T P G V N S S A S L S P D R L N-termC-term L F C R I G G S R R E R S G Q H C S D S Q R T S S A M S G H S R S F I S R E L K E I S S T S Q T L L P D L S L P D L S E N G L G G R N L L P G V P G M G L A Q E D T T S L R T L R I S E T S D S S Q G Q D S E S V L L V D E A G G S G R A G P A P K G S S L Q V T F P S E T L N L S E K C I C-term N S P V T I P A V M F I F G V V G N L V A I V V L C K S T T F Y T L V C G L A V T D L L G T L L V S P V T I A T Y M K G Q P L C E Y S T F I L L F F S L S G L S I I C A M S V E R Y L A I N H D K R L A G L T L F A V Y A S N V L F C A L P N M G V T A H A A Y S Y M Y A G F S S F L I L A T V L C N V L V C G A L L R M H R Q F M R R T R R I A G A E I Q M V I L L I A T S L V V L I C S I P L V V R V F V N Q L Y N P D L Q A I R I A S V N P I L D P W I Y I L L R K T A I E V L S K K I K C
Helix box plot — Download: PNG | SVG L N G V V G F I F M V A P I T V P S N 1 C G L A V T D L L G T L L V S P V T I A 2 A C I I S L G S L S F F L L I F T S Y E 3 A G L T L F A V Y A S N V L F C A L P N 4 N C L V T A L I L F S S F G A Y M Y S Y 5 I A T S L V V L I C S I P L V V R V F V 6 W P D L I P N V S A I R I A Q L D P N 7

GPCRdb(A)
GPCRdb(A)
EP4 receptor
TM1
1x42 1.42x42 M27
TM2
2x54 2.54x54 T69
2x57 2.57x57 V72
2x61 2.61x61 T76
TM3
3x32 3.32x32 L99
TM7
7x38 7.39x38 I315
7x42 7.43x42 S319