Structure information

EP3 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8GDC

SPECIES

Homo sapiens

RESOLUTION

3.500

PREFERRED CHAIN

R

REFERENCE

10.1073/PNAS.2216329120

PUBLICATION DATE

Jan. 10, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
PGE<sub>2</sub> P55 1.39x39 TM1 hydrophobic
PGE<sub>2</sub> M58 1.42x42 TM1 polar (hydrogen bond)
PGE<sub>2</sub> G102 2.53x53 TM2 Van der Waals
PGE<sub>2</sub> G102 2.53x53 TM2 polar (hydrogen bond with backbone)
PGE<sub>2</sub> Q103 2.54x54 TM2 polar (hydrogen bond)
PGE<sub>2</sub> Q103 2.54x54 TM2 Van der Waals
PGE<sub>2</sub> T107 2.58x58 TM2 Van der Waals
PGE<sub>2</sub> M137 3.32x32 TM3 hydrophobic
PGE<sub>2</sub> M137 3.32x32 TM3 Van der Waals
PGE<sub>2</sub> G141 3.36x36 TM3 Van der Waals
PGE<sub>2</sub> W207 ECL2 hydrophobic
PGE<sub>2</sub> W207 ECL2 Van der Waals
PGE<sub>2</sub> F209 45.51x51 ECL2 hydrophobic
PGE<sub>2</sub> W295 6.48x48 TM6 Van der Waals
PGE<sub>2</sub> W295 6.48x48 TM6 hydrophobic
PGE<sub>2</sub> R333 7.40x39 TM7 polar (charge-assisted hydrogen bond)
PGE<sub>2</sub> S336 7.43x42 TM7 Van der Waals

Ligands

PGE<sub>2</sub>

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Residue Diagrams

A N G V F G T L L M T I P F A V 1 G W L A L T D L V G Q L L T T P V V I V 2 A S A I F L S S L G F V T M T L G F F T 3 T R A V L L G V W L A V L A F A L L P V 4 N C S F T V T L A L L G L F A F A S A F 5 M G I M C V L S V C W S P L L I M M L K 6 W P D L I Q N L S A L R V A I L F F N 7
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ICL1 R R E S K R ICL1ECL1 Q R W E H I D P S ECL1ICL2 P H W Y A S H M ICL2ECL2 V G Q Y T V Q W P G T W C F I S T G R G G N G T S S S H N ECL2ICL3 T A S Q ICL3ECL3 V E H C K ECL3N-term M K E T R G Y G G D A P F C T R L N H S Y T G M W A P E R S A E A R G N L T R P P G S G E D C G S V S N-termC-term S S T S L P C Q C S S T L M W S D H L E R C-term V A F P I T M L L T G F V G N A L A M L L V S R S Y R K K S F L L C I G W L A L T D L V G Q L L T T P V V I V V Y L S K G R L C T F F G L T M T V F G L S S L F I A S A M A V E R A L A I R A K T R A T R A V L L G V W L A V L A F A L L P V L G W G N L F F A S A F A F L G L L A L T V T F S C N L A T I K A L V S R C R A K A S S A Q W G R I T T E T A I Q L M G I M C V L S V C W S P L L I M M L K M I F N Q T S T H T E K Q K E C N F F L I A V R L A S L N Q I L D P W V Y L L L R K I F C Q T N N L L R K I R Y H Y A S
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Residue Table


GPCRdb(A)
GPCRdb(A)
EP3 receptor
TM1
1x39 1.39x39 P55
1x42 1.42x42 M58
TM2
2x53 2.53x53 G102
2x54 2.54x54 Q103
2x58 2.58x58 T107
TM3
3x32 3.32x32 M137
3x36 3.36x36 G141
ECL2
45x51 45.51x51 F209
TM6
6x48 6.48x48 W295
TM7
7x39 7.40x39 R333
7x42 7.43x42 S336