Structure information

CB2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8GUQ

SPECIES

Homo sapiens

RESOLUTION

3.080

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-023-37112-9

PUBLICATION DATE

May 10, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
olorinab F94 2.64x64 TM2 hydrophobic
olorinab I110 3.29x29 TM3 hydrophobic
olorinab T114 3.33x33 TM3 polar (hydrogen bond)
olorinab T114 3.33x33 TM3 Van der Waals
olorinab F117 3.36x36 TM3 Van der Waals
olorinab F117 3.36x36 TM3 hydrophobic
olorinab F183 ECL2 Van der Waals
olorinab F183 ECL2 aromatic (face-to-face)
olorinab I186 ECL2 Van der Waals
olorinab L191 5.40x40 TM5 Van der Waals
olorinab W194 5.43x43 TM5 aromatic (face-to-edge)
olorinab W194 5.43x43 TM5 Van der Waals
olorinab W258 6.48x48 TM6 Van der Waals
olorinab S285 7.39x38 TM7 Van der Waals
olorinab S285 7.39x38 TM7 polar (hydrogen bond)

Ligands

olorinab

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Residue Diagrams

V N E L A S L L G L L T C L V A V A T K 1 G S L A G A D F L A S V V F A C S F V N 2 L L L S G V S A T F T M T V S G I K L L 3 A L V T L G I M W V L S A L V S Y L P L 4 Y T Y I I G S F L F A I F L L W S L L Y 5 G L V L A V L L I C W F P V L A L M A H 6 V P N V M S N I L C L M S C F A F A K 7
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ICL1 H Q L R R ICL1ECL1 F H G V D ECL1ICL2 P P S Y K A L L ICL2ECL2 W T C C P R P C S E L F P L I ECL2ICL3 H Q D R Q V P G M A R M ICL3ECL3 T L ECL3N-term M E E C W V T E I A N G S K D G L D S N P M K D Y M I L N-termC-term C V R G L G S E A K E E A P R S S V T E T E A D G K I T P W P D S R D L D L S D C C-term S G P Q K T A V A V L C T L L G L L S A L E N V A V L Y L I L S S K P S Y L F I G S L A G A D F L A S V V F A C S F V N F H V S K A V F L L K I G S V T M T F T A S V G S L L L T A I D R Y L C L R Y T R G R A L V T L G I M W V L S A L V S Y L P L M G P N D Y L L S W L L F I A F L F S G I I Y T Y G H V L W K A H Q H V A S L S G R L D V R L A K T L G L V L A V L L I C W F P V L A L M A H S L A T S D Q V K K A F A F C S M L C L I N S M V N P V I Y A L R S G E A H H W K K I R S S C L A H
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Residue Table


GPCRdb(A)
GPCRdb(A)
CB2 receptor
TM2
2x64 2.64x64 F94
TM3
3x29 3.29x29 I110
3x33 3.33x33 T114
3x36 3.36x36 F117
TM5
5x40 5.40x40 L191
5x43 5.43x43 W194
TM6
6x48 6.48x48 W258
TM7
7x38 7.39x38 S285