Structure information

CB2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8GUR

SPECIES

Homo sapiens

RESOLUTION

2.840

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-023-37112-9

PUBLICATION DATE

May 10, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CP55940 F87 2.57x57 TM2 aromatic (edge-to-face)
CP55940 F91 2.61x61 TM2 hydrophobic
CP55940 F94 2.64x64 TM2 hydrophobic
CP55940 I110 3.29x29 TM3 hydrophobic
CP55940 F117 3.36x36 TM3 hydrophobic
CP55940 L182 ECL2 polar (hydrogen bond with backbone)
CP55940 L182 ECL2 Van der Waals
CP55940 F183 ECL2 hydrophobic
CP55940 F183 ECL2 Van der Waals
CP55940 P184 ECL2 hydrophobic
CP55940 P184 ECL2 Van der Waals
CP55940 I186 ECL2 hydrophobic
CP55940 I186 ECL2 Van der Waals
CP55940 W194 5.43x43 TM5 Van der Waals
CP55940 W194 5.43x43 TM5 hydrophobic
CP55940 F281 7.35x34 TM7 Van der Waals
CP55940 F281 7.35x34 TM7 hydrophobic
CP55940 S285 7.39x38 TM7 Van der Waals
CP55940 S285 7.39x38 TM7 polar (hydrogen bond)

Ligands

CP55940

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Residue Diagrams

V N E L A S L L G L L T C L V A V A T K 1 G S L A G A D F L A S V V F A C S F V N 2 L L L S G V S A T F T M T V S G I K L L 3 A L V T L G I M W V L S A L V S Y L P L 4 Y T Y I I G S F L F A I F L L W S L L Y 5 G L V L A V L L I C W F P V L A L M A H 6 V P N V M S N I L C L M S C F A F A K 7
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ICL1 H Q L R R ICL1ECL1 F H G V D ECL1ICL2 P P S Y K A L L ICL2ECL2 W T C C P R P C S E L F P L I ECL2ICL3 H Q D R Q V P G M A R M ICL3ECL3 T L ECL3N-term M E E C W V T E I A N G S K D G L D S N P M K D Y M I L N-termC-term C V R G L G S E A K E E A P R S S V T E T E A D G K I T P W P D S R D L D L S D C C-term S G P Q K T A V A V L C T L L G L L S A L E N V A V L Y L I L S S K P S Y L F I G S L A G A D F L A S V V F A C S F V N F H V S K A V F L L K I G S V T M T F T A S V G S L L L T A I D R Y L C L R Y T R G R A L V T L G I M W V L S A L V S Y L P L M G P N D Y L L S W L L F I A F L F S G I I Y T Y G H V L W K A H Q H V A S L S G R L D V R L A K T L G L V L A V L L I C W F P V L A L M A H S L A T S D Q V K K A F A F C S M L C L I N S M V N P V I Y A L R S G E A H H W K K I R S S C L A H
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Residue Table


GPCRdb(A)
GPCRdb(A)
CB2 receptor
TM2
2x57 2.57x57 F87
2x61 2.61x61 F91
2x64 2.64x64 F94
TM3
3x29 3.29x29 I110
3x36 3.36x36 F117
TM5
5x43 5.43x43 W194
TM7
7x34 7.35x34 F281
7x38 7.39x38 S285