PDB
8GUR
Resolution
2.8 Å
Released
May 10, 2023
Receptor
CB2
Class
A
Species
Homo sapiens
Ligand
Function
CP55940
Agonist
Reference
10.1038/S41467-023-37112-9

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Ligand Amino Acid Generic Number Segment Interaction Type
CP55940 F87 2.57x57 TM2 aromatic (edge-to-face)
CP55940 F87 2.57x57 TM2 hydrophobic
CP55940 S90 2.60x60 TM2 Van der Waals
CP55940 F91 2.61x61 TM2 hydrophobic
CP55940 F94 2.64x64 TM2 hydrophobic
CP55940 I110 3.29x29 TM3 hydrophobic
CP55940 V113 3.32x32 TM3 Van der Waals
CP55940 T114 3.33x33 TM3 hydrophobic
CP55940 F117 3.36x36 TM3 hydrophobic
CP55940 L182 ECL2 polar (hydrogen bond with backbone)
CP55940 F183 ECL2 hydrophobic
CP55940 P184 ECL2 hydrophobic
CP55940 I186 ECL2 hydrophobic
CP55940 W194 5.43x43 TM5 hydrophobic
CP55940 M265 6.55x55 TM6 hydrophobic
CP55940 F281 7.35x34 TM7 hydrophobic
CP55940 S285 7.39x38 TM7 polar (hydrogen bond)
CP55940 C288 7.42x41 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 H Q L R R ICL1ECL1 F H G V D ECL1ICL2 P P S Y K A L L ICL2ECL2 W T C C P R P C S E L F P L I ECL2ICL3 H Q D R Q V P G M A R M ICL3ECL3 T L ECL3N-term M E E C W V T E I A N G S K D G L D S N P M K D Y M I L N-termC-term C V R G L G S E A K E E A P R S S V T E T E A D G K I T P W P D S R D L D L S D C C-term S G P Q K T A V A V L C T L L G L L S A L E N V A V L Y L I L S S K P S Y L F I G S L A G A D F L A S V V F A C S F V N F H V S K A V F L L K I G S V T M T F T A S V G S L L L T A I D R Y L C L R Y T R G R A L V T L G I M W V L S A L V S Y L P L M G P N D Y L L S W L L F I A F L F S G I I Y T Y G H V L W K A H Q H V A S L S G R L D V R L A K T L G L V L A V L L I C W F P V L A L M A H S L A T S D Q V K K A F A F C S M L C L I N S M V N P V I Y A L R S G E A H H W K K I R S S C L A H
Helix box plot — Download: PNG | SVG V N E L A S L L G L L T C L V A V A T K 1 G S L A G A D F L A S V V F A C S F V N 2 L L L S G V S A T F T M T V S G I K L L 3 A L V T L G I M W V L S A L V S Y L P L 4 Y T Y I I G S F L F A I F L L W S L L Y 5 G L V L A V L L I C W F P V L A L M A H 6 V P N V M S N I L C L M S C F A F A K 7

GPCRdb(A)
GPCRdb(A)
CB2 receptor
TM2
2x57 2.57x57 F87
2x60 2.60x60 S90
2x61 2.61x61 F91
2x64 2.64x64 F94
TM3
3x29 3.29x29 I110
3x32 3.32x32 V113
3x33 3.33x33 T114
3x36 3.36x36 F117
TM5
5x43 5.43x43 W194
TM6
6x55 6.55x55 M265
TM7
7x34 7.35x34 F281
7x38 7.39x38 S285
7x41 7.42x41 C288