Structure information

CB2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8GUS

SPECIES

Homo sapiens

RESOLUTION

2.970

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-023-37112-9

PUBLICATION DATE

May 10, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL2179724 F87 2.57x57 TM2 aromatic (edge-to-face)
CHEMBL2179724 F91 2.61x61 TM2 hydrophobic
CHEMBL2179724 F94 2.64x64 TM2 hydrophobic
CHEMBL2179724 F106 3.25x25 TM3 hydrophobic
CHEMBL2179724 I110 3.29x29 TM3 hydrophobic
CHEMBL2179724 V113 3.32x32 TM3 hydrophobic
CHEMBL2179724 F117 3.36x36 TM3 hydrophobic
CHEMBL2179724 F183 ECL2 hydrophobic
CHEMBL2179724 P184 ECL2 hydrophobic
CHEMBL2179724 Y190 5.39x39 TM5 hydrophobic
CHEMBL2179724 W194 5.43x43 TM5 hydrophobic
CHEMBL2179724 W258 6.48x48 TM6 hydrophobic
CHEMBL2179724 F281 7.35x34 TM7 hydrophobic

Ligands

CHEMBL2179724

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Residue Diagrams

V N E L A S L L G L L T C L V A V A T K 1 G S L A G A D F L A S V V F A C S F V N 2 L L L S G V S A T F T M T V S G I K L L 3 A L V T L G I M W V L S A L V S Y L P L 4 Y T Y I I G S F L F A I F L L W S L L Y 5 G L V L A V L L I C W F P V L A L M A H 6 V P N V M S N I L C L M S C F A F A K 7
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ICL1 H Q L R R ICL1ECL1 F H G V D ECL1ICL2 P P S Y K A L L ICL2ECL2 W T C C P R P C S E L F P L I ECL2ICL3 H Q D R Q V P G M A R M ICL3ECL3 T L ECL3N-term M E E C W V T E I A N G S K D G L D S N P M K D Y M I L N-termC-term C V R G L G S E A K E E A P R S S V T E T E A D G K I T P W P D S R D L D L S D C C-term S G P Q K T A V A V L C T L L G L L S A L E N V A V L Y L I L S S K P S Y L F I G S L A G A D F L A S V V F A C S F V N F H V S K A V F L L K I G S V T M T F T A S V G S L L L T A I D R Y L C L R Y T R G R A L V T L G I M W V L S A L V S Y L P L M G P N D Y L L S W L L F I A F L F S G I I Y T Y G H V L W K A H Q H V A S L S G R L D V R L A K T L G L V L A V L L I C W F P V L A L M A H S L A T S D Q V K K A F A F C S M L C L I N S M V N P V I Y A L R S G E A H H W K K I R S S C L A H
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Residue Table


GPCRdb(A)
GPCRdb(A)
CB2 receptor
TM2
2x57 2.57x57 F87
2x61 2.61x61 F91
2x64 2.64x64 F94
TM3
3x25 3.25x25 F106
3x29 3.29x29 I110
3x32 3.32x32 V113
3x36 3.36x36 F117
TM5
5x39 5.39x39 Y190
5x43 5.43x43 W194
TM6
6x48 6.48x48 W258
TM7
7x34 7.35x34 F281