Structure information

FFA4 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8H4I

SPECIES

Homo sapiens

RESOLUTION

3.060

PREFERRED CHAIN

R

REFERENCE

10.1038/S41422-023-00835-X

PUBLICATION DATE

June 21, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
docosahexaenoic acid F27 N-term hydrophobic
docosahexaenoic acid M118 3.32x32 TM3 hydrophobic
docosahexaenoic acid W198 ECL2 Van der Waals
docosahexaenoic acid W198 ECL2 polar (hydrogen bond)
docosahexaenoic acid E204 5.35x36 TM5 polar (charge-assisted hydrogen bond)
docosahexaenoic acid D208 5.39x40 TM5 Van der Waals
docosahexaenoic acid F211 5.42x43 TM5 Van der Waals
docosahexaenoic acid F211 5.42x43 TM5 hydrophobic
docosahexaenoic acid N215 5.46x461 TM5 Van der Waals
docosahexaenoic acid I280 6.51x51 TM6 hydrophobic
docosahexaenoic acid I280 6.51x51 TM6 Van der Waals
docosahexaenoic acid I284 6.55x55 TM6 hydrophobic
docosahexaenoic acid I284 6.55x55 TM6 Van der Waals
docosahexaenoic acid L288 6.59x59 TM6 hydrophobic
docosahexaenoic acid L288 6.59x59 TM6 Van der Waals

Ligands

docosahexaenoic acid

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Residue Diagrams

V N G L L S V A F I L V L V T T E V A A 1 L N L F C A D L L F I S A I P L V L A V 2 A A L T L I T V S G S L T M V Y F L L H 3 R A V L L A L I W G Y S A V A A L P L 4 Y S I V I V L G P V L F N L T V F S V D W 5 L F L L M V S F I F M W S P I I I T I L L 6 I P N L A S N A F T F A V V W F F L S 7
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ICL1 R R R G A T ICL1ECL1 E A W L L ECL1ICL2 L Q R G V R G P ICL2ECL2 R V V P Q R L P G A D Q E I S I C T L I W P ECL2ICL3 A Y ICL3ECL3 D L V I ECL3N-term M S P E C A R A A G D A P L R S L E Q A N R T R F P F F S D V K G D N-termC-term P E K G A I L T D T S V K R N D L S I I S G C-term H R L V L A A V E T T V L V L I F A V S L L G N V C A L V L V A R R A C L V L N L F C A D L L F I S A I P L V L A V R W T G P V A C H L L F Y V M T L S G S V T I L T L A A V S L E R M V C I V H G R R A R A V L L A L I W G Y S A V A A L P L C V F F T I P G E I S W D V S F V T L N F L V P G L V I V I S Y S K I L Q I T K A S R K R L T V S L S E S H Q I R V S Q Q D F R L F R T L F L L M V S F F I M W S P I I I T I L L I L I Q N F K Q W P S L F F W V V A F T F A N S A L N P I L Y N M T L C R K I F F N E W K C C F W
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Residue Table


GPCRdb(A)
GPCRdb(A)
FFA4 receptor
TM3
3x32 3.32x32 M118
TM5
5x36 5.35x36 E204
5x40 5.39x40 D208
5x43 5.42x43 F211
5x461 5.46x461 N215
TM6
6x51 6.51x51 I280
6x55 6.55x55 I284
6x59 6.59x59 L288