PDB
8H4L
Resolution
3.1 Å
Released
June 21, 2023
Receptor
FFA4
Class
A
Species
Homo sapiens
Ligand
Function
docosahexaenoic acid
Agonist
Reference
10.1038/S41422-023-00835-X

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Ligand Amino Acid Generic Number Segment Interaction Type
docosahexaenoic acid F27 N-term hydrophobic
docosahexaenoic acid F88 2.53x53 TM2 hydrophobic
docosahexaenoic acid F115 3.29x29 TM3 hydrophobic
docosahexaenoic acid M118 3.32x32 TM3 hydrophobic
docosahexaenoic acid T119 3.33x33 TM3 Van der Waals
docosahexaenoic acid G122 3.36x36 TM3 Van der Waals
docosahexaenoic acid S123 3.37x37 TM3 Van der Waals
docosahexaenoic acid I126 3.40x40 TM3 hydrophobic
docosahexaenoic acid L173 4.60x61 TM4 Van der Waals
docosahexaenoic acid L196 45.52x52 ECL2 hydrophobic
docosahexaenoic acid E204 5.35x36 TM5 Van der Waals
docosahexaenoic acid W207 5.38x39 TM5 hydrophobic
docosahexaenoic acid D208 5.39x40 TM5 Van der Waals
docosahexaenoic acid F211 5.42x43 TM5 hydrophobic
docosahexaenoic acid N215 5.46x461 TM5 hydrophobic
docosahexaenoic acid W277 6.48x48 TM6 hydrophobic
docosahexaenoic acid I281 6.52x52 TM6 hydrophobic
docosahexaenoic acid I284 6.55x55 TM6 hydrophobic
docosahexaenoic acid I287 6.58x58 TM6 Van der Waals
docosahexaenoic acid L288 6.59x59 TM6 Van der Waals
docosahexaenoic acid F303 7.35x34 TM7 Van der Waals
docosahexaenoic acid V307 7.39x38 TM7 Van der Waals
docosahexaenoic acid T310 7.42x41 TM7 hydrophobic

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ICL1 R R R G A T ICL1ECL1 E A W L L ECL1ICL2 L Q R G V R G P ICL2ECL2 R V V P Q R L P G A D Q E I S I C T L I W P ECL2ICL3 A Y ICL3ECL3 D L V I ECL3N-term M S P E C A R A A G D A P L R S L E Q A N R T R F P F F S D V K G D N-termC-term P E K G A I L T D T S V K R N D L S I I S G C-term H R L V L A A V E T T V L V L I F A V S L L G N V C A L V L V A R R A C L V L N L F C A D L L F I S A I P L V L A V R W T G P V A C H L L F Y V M T L S G S V T I L T L A A V S L E R M V C I V H G R R A R A V L L A L I W G Y S A V A A L P L C V F F T I P G E I S W D V S F V T L N F L V P G L V I V I S Y S K I L Q I T K A S R K R L T V S L S E S H Q I R V S Q Q D F R L F R T L F L L M V S F F I M W S P I I I T I L L I L I Q N F K Q W P S L F F W V V A F T F A N S A L N P I L Y N M T L C R K I F F N E W K C C F W
Helix box plot — Download: PNG | SVG V N G L L S V A F I L V L V T T E V A A 1 L N L F C A D L L F I S A I P L V L A V 2 A A L T L I T V S G S L T M V Y F L L H 3 R A V L L A L I W G Y S A V A A L P L 4 Y S I V I V L G P V L F N L T V F S V D W 5 L F L L M V S F I F M W S P I I I T I L L 6 I P N L A S N A F T F A V V W F F L S 7

GPCRdb(A)
GPCRdb(A)
FFA4 receptor
TM2
2x53 2.53x53 F88
TM3
3x29 3.29x29 F115
3x32 3.32x32 M118
3x33 3.33x33 T119
3x36 3.36x36 G122
3x37 3.37x37 S123
3x40 3.40x40 I126
TM4
4x61 4.60x61 L173
ECL2
45x52 45.52x52 L196
TM5
5x36 5.35x36 E204
5x39 5.38x39 W207
5x40 5.39x40 D208
5x43 5.42x43 F211
5x461 5.46x461 N215
TM6
6x48 6.48x48 W277
6x52 6.52x52 I281
6x55 6.55x55 I284
6x58 6.58x58 I287
6x59 6.59x59 L288
TM7
7x34 7.35x34 F303
7x38 7.39x38 V307
7x41 7.42x41 T310