Structure information

FFA4 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8H4L

SPECIES

Homo sapiens

RESOLUTION

3.070

PREFERRED CHAIN

R

REFERENCE

10.1038/S41422-023-00835-X

PUBLICATION DATE

June 21, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
docosahexaenoic acid F27 N-term hydrophobic
docosahexaenoic acid F88 2.53x53 TM2 hydrophobic
docosahexaenoic acid M118 3.32x32 TM3 hydrophobic
docosahexaenoic acid D208 5.39x40 TM5 polar (charge-assisted hydrogen bond)
docosahexaenoic acid F211 5.42x43 TM5 hydrophobic
docosahexaenoic acid F211 5.42x43 TM5 Van der Waals
docosahexaenoic acid N215 5.46x461 TM5 Van der Waals
docosahexaenoic acid W277 6.48x48 TM6 Van der Waals
docosahexaenoic acid W277 6.48x48 TM6 hydrophobic
docosahexaenoic acid I284 6.55x55 TM6 hydrophobic
docosahexaenoic acid I287 6.58x58 TM6 Van der Waals
docosahexaenoic acid I287 6.58x58 TM6 hydrophobic

Ligands

docosahexaenoic acid

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Residue Diagrams

V N G L L S V A F I L V L V T T E V A A 1 L N L F C A D L L F I S A I P L V L A V 2 A A L T L I T V S G S L T M V Y F L L H 3 R A V L L A L I W G Y S A V A A L P L 4 Y S I V I V L G P V L F N L T V F S V D W 5 L F L L M V S F I F M W S P I I I T I L L 6 I P N L A S N A F T F A V V W F F L S 7
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ICL1 R R R G A T ICL1ECL1 E A W L L ECL1ICL2 L Q R G V R G P ICL2ECL2 R V V P Q R L P G A D Q E I S I C T L I W P ECL2ICL3 A Y ICL3ECL3 D L V I ECL3N-term M S P E C A R A A G D A P L R S L E Q A N R T R F P F F S D V K G D N-termC-term P E K G A I L T D T S V K R N D L S I I S G C-term H R L V L A A V E T T V L V L I F A V S L L G N V C A L V L V A R R A C L V L N L F C A D L L F I S A I P L V L A V R W T G P V A C H L L F Y V M T L S G S V T I L T L A A V S L E R M V C I V H G R R A R A V L L A L I W G Y S A V A A L P L C V F F T I P G E I S W D V S F V T L N F L V P G L V I V I S Y S K I L Q I T K A S R K R L T V S L S E S H Q I R V S Q Q D F R L F R T L F L L M V S F F I M W S P I I I T I L L I L I Q N F K Q W P S L F F W V V A F T F A N S A L N P I L Y N M T L C R K I F F N E W K C C F W
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Residue Table


GPCRdb(A)
GPCRdb(A)
FFA4 receptor
TM2
2x53 2.53x53 F88
TM3
3x32 3.32x32 M118
TM5
5x40 5.39x40 D208
5x43 5.42x43 F211
5x461 5.46x461 N215
TM6
6x48 6.48x48 W277
6x55 6.55x55 I284
6x58 6.58x58 I287