Structure information

GPR35

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8H8J

SPECIES

Homo sapiens

RESOLUTION

3.200

PREFERRED CHAIN

C

REFERENCE

10.1038/S41421-022-00499-8

PUBLICATION DATE

Feb. 8, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
lodoxamide L80 ECL1 hydrophobic
lodoxamide F163 45.51x51 ECL2 polar (hydrogen bond with backbone)
lodoxamide F163 45.51x51 ECL2 Van der Waals
lodoxamide R164 45.52x52 ECL2 Van der Waals
lodoxamide R240 6.58x58 TM6 polar (charge-assisted hydrogen bond)
lodoxamide L258 7.35x34 TM7 Van der Waals
lodoxamide L258 7.35x34 TM7 hydrophobic
lodoxamide Y259 7.36x35 TM7 Van der Waals
lodoxamide Y259 7.36x35 TM7 aromatic (edge-to-face)
lodoxamide S262 7.39x38 TM7 Van der Waals

Ligands

lodoxamide

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Residue Diagrams

S N L L L G L V L L V G L Y A Y F G L K 1 T N L A V A D L C L L C T L P F V L H S 2 A T V L S I S M Y R N T L Y I G Q S L Q 3 A A A V C A V L W V L V I G S L V A R W 4 S C F V V V A L P L Y F G L L P F A M 5 W A N L L V F V V C F L P L H V G L T V 6 I A D L C C N A D S L K S T I Y L A R 7
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ICL1 M Q Q W ICL1ECL1 L R D T S D ECL1ICL2 P L R A R G L R ICL2ECL2 G G F C F R S T R H N F N S ECL2ICL3 P P T ICL3ECL3 G W N A C ECL3N-term M N G T Y N T C G S S D L T W N-termC-term V A P S A K A H K S Q D S L C V T L A C-term P P A I K L G F Y A Y L G V L L V L G L L L N S L A L W V F C C R T E T R I Y M T N L A V A D L C L L C T L P F V L H S T P L C Q L S Q G I Y L T N R Y M S I S L V T A I A V D R Y V A V R H S P R Q A A A V C A V L W V L V I G S L V A R W L L G I Q E M A F P L L G F Y L P L A V V V F C S L K V V T A L A Q R D V G Q A E A T R K A A R M V W A N L L V F V V C F L P L H V G L T V R L A V A L L E T I R R A L Y I T S K L S D A N C C L D A I C Y Y Y M A K E S A L F Q E A A
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Residue Table


GPCRdb(A)
GPCRdb(A)
GPR35
ECL2
45x51 45.51x51 F163
45x52 45.52x52 R164
TM6
6x58 6.58x58 R240
TM7
7x34 7.35x34 L258
7x35 7.36x35 Y259
7x38 7.39x38 S262