PDB
8HCQ
Resolution
3.0 Å
Released
March 22, 2023
Receptor
ETA
Class
A
Species
Homo sapiens
Ligand
endothelin-1 (Human)
Function
Agonist
Reference
—

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
endothelin-1 (Human) K74 N-term polar (charge-assisted hydrogen bond)
endothelin-1 (Human) I136 2.60x59 TM2 Van der Waals
endothelin-1 (Human) N137 2.61x60 TM2 Van der Waals
endothelin-1 (Human) K140 2.64x63 TM2 polar (charge-assisted hydrogen bond)
endothelin-1 (Human) G144 ECL1 Van der Waals
endothelin-1 (Human) G144 ECL1 polar (hydrogen bond with backbone)
endothelin-1 (Human) R145 23.49x49 ECL1 Van der Waals
endothelin-1 (Human) Q165 3.32x32 TM3 Van der Waals
endothelin-1 (Human) K166 3.33x33 TM3 polar (charge-assisted hydrogen bond)
endothelin-1 (Human) F229 ECL2 Van der Waals
endothelin-1 (Human) F229 ECL2 hydrophobic
endothelin-1 (Human) Y231 ECL2 Van der Waals
endothelin-1 (Human) Y231 ECL2 hydrophobic
endothelin-1 (Human) K237 ECL2 Van der Waals
endothelin-1 (Human) T238 ECL2 Van der Waals
endothelin-1 (Human) T238 ECL2 polar (hydrogen bond)
endothelin-1 (Human) M240 45.51x51 ECL2 hydrophobic
endothelin-1 (Human) M240 45.51x51 ECL2 Van der Waals
endothelin-1 (Human) L241 45.52x52 ECL2 Van der Waals
endothelin-1 (Human) Q252 5.35x36 TM5 Van der Waals
endothelin-1 (Human) Q252 5.35x36 TM5 polar (hydrogen bond)
endothelin-1 (Human) Q252 5.35x36 TM5 polar (hydrogen bond with backbone)
endothelin-1 (Human) K255 5.38x39 TM5 polar (charge-assisted hydrogen bond)
endothelin-1 (Human) L259 5.42x43 TM5 Van der Waals
endothelin-1 (Human) L259 5.42x43 TM5 hydrophobic
endothelin-1 (Human) W319 6.48x48 TM6 Van der Waals
endothelin-1 (Human) W319 6.48x48 TM6 hydrophobic
endothelin-1 (Human) R326 6.55x55 TM6 polar (charge-assisted hydrogen bond)
endothelin-1 (Human) K330 6.59x59 TM6 Van der Waals
endothelin-1 (Human) M336 ECL3 hydrophobic
endothelin-1 (Human) M336 ECL3 Van der Waals
endothelin-1 (Human) L344 7.28x27 TM7 hydrophobic
endothelin-1 (Human) L344 7.28x27 TM7 Van der Waals
endothelin-1 (Human) L348 7.32x31 TM7 Van der Waals
endothelin-1 (Human) L348 7.32x31 TM7 hydrophobic
endothelin-1 (Human) D351 7.35x34 TM7 polar (charge-assisted hydrogen bond)
endothelin-1 (Human) I355 7.39x38 TM7 Van der Waals
endothelin-1 (Human) I355 7.39x38 TM7 hydrophobic

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 K C M R ICL1ECL1 G R W P F D H ECL1ICL2 W S R V Q G I G ICL2ECL2 V M V P F E Y R G E Q H K T C M L N A T ECL2ICL3 L R I A L ICL3ECL3 N E M D K N ECL3N-term M E T L C L R A S F W L A L V G C V I S D N P E R Y S T N L S N H V D D F T T F R G T E L S F L V T T H Q P T N L V L P S N G S M H N Y C N-termC-term C C Y Q S K S L M T S V P M N G T S I Q W K N H D Q N N H N T D R S S H K D S M N C-term P Q Q T K I T S A F K Y I N T V I S C T I F I V G M V G N A T L L R I I Y Q N N G P N A L I A S L A L G D L I Y V V I D L P I N V F K L L A N D F G V F L C K L F P F L Q K S S V G I T V L N L C A L S V D R Y R A V A S I P L V T A I E I V S I W I L S F I L A I P E A I G F S K F M E F Y Q D V K D W W L F G F Y F C M P L V C T A I F Y T L M T C E M L N R R N G S S E H L K Q R R E V A K T V F C L V V I F A L C W F P L H L S R I L K K T V Y R C E L L S F L L L M D Y I G I N L A T M N S C I N P I A L Y F V S K K F Q S F K N C C L C C
Helix box plot — Download: PNG | SVG A N G V M G V I F I T C S I V T N I Y K 1 A S L A L G D L I Y V I V D L P I N V F K 2 A C L N L V T I G V S S K Q L F P F L K 3 T A I E I V S I W I L S F I L A I P E 4 Y F I A T C V L P M C F Y F G F L W W D K 5 F C L V V I F A L C W F P L H L S R I L 6 I P N I C S N M T A L N I G I Y D M L 7

GPCRdb(A)
GPCRdb(A)
ETA receptor
TM2
2x59 2.60x59 I136
2x60 2.61x60 N137
2x63 2.64x63 K140
ECL1
23x49 23.49x49 R145
TM3
3x32 3.32x32 Q165
3x33 3.33x33 K166
ECL2
45x51 45.51x51 M240
45x52 45.52x52 L241
TM5
5x36 5.35x36 Q252
5x39 5.38x39 K255
5x43 5.42x43 L259
TM6
6x48 6.48x48 W319
6x55 6.55x55 R326
6x59 6.59x59 K330
TM7
7x27 7.28x27 L344
7x31 7.32x31 L348
7x34 7.35x34 D351
7x38 7.39x38 I355