Structure information

MRGPRX1

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8HJ5

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

F

REFERENCE

PUBLICATION DATE

May 31, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
compound 16 [PMID: 31498617] K96 3.26x26 TM3 polar (charge-assisted hydrogen bond)
compound 16 [PMID: 31498617] Y99 3.29x29 TM3 aromatic (face-to-edge)
compound 16 [PMID: 31498617] Y99 3.29x29 TM3 Van der Waals
compound 16 [PMID: 31498617] E157 4.60x60 TM4 polar (charge-assisted hydrogen bond)
compound 16 [PMID: 31498617] W158 4.61x61 TM4 aromatic (edge-to-face)
compound 16 [PMID: 31498617] W158 4.61x61 TM4 Van der Waals
compound 16 [PMID: 31498617] C173 5.36x36 TM5 polar (hydrogen bond)
compound 16 [PMID: 31498617] C173 5.36x36 TM5 Van der Waals
compound 16 [PMID: 31498617] D177 5.40x40 TM5 polar (charge-assisted hydrogen bond)
compound 16 [PMID: 31498617] F236 6.55x55 TM6 hydrophobic
compound 16 [PMID: 31498617] L240 6.59x59 TM6 Van der Waals
compound 16 [PMID: 31498617] L240 6.59x59 TM6 hydrophobic

Ligands

compound 16 [PMID: 31498617]

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Residue Diagrams

A N G T L G V L S V I C T L V T L S L T 1 L N L A A A D F L F L S G R L I Y S L L 2 A S L F S L G A F Y S F M M V P Y L I K 3 S A V V C V L L W A L S L L R S I L E W 4 S S G C L V V C L F I L W A V T I F D S 5 L L T V L V F L L C G L P F G I Q F F L 6 I P N A S S N L A S L F I S V L H V H 7
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ICL1 R R ICL1ECL1 S I P H T ECL1ICL2 P I W Y R C H R ICL2ECL2 G F L F S G A ECL2ICL3 G S R K I ICL3ECL3 V D R E V ECL3N-term M D P T I S T L D T E L T P I N G T E E T L C Y K N-termC-term Q R Q N R Q N L K L V L Q R A L Q D A S E V D E G G G Q L P E E I L E L S G S R L E Q C-term Q T L S L T V L T C I V S L V G L T G N A V V L W L L G C R M N A F S I Y I L N L A A A D F L F L S G R L I Y S L L S F I I S K I L Y P V M M F S Y F A G L S F L S A V S T E R C L S V L W P T H L S A V V C V L L W A L S L L R S I L E W M L C D S A W C Q T S D F I T V A W L I F L C V V L C G S S L V L L I R I L C P L T R L Y V T I L L T V L V F L L C G L P F G I Q F F L F L W I H L F C H V H L V S I F L S A L N S S A N P I I Y F F V G S F R
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Residue Table


GPCRdb(A)
GPCRdb(A)
MRGPRX1
TM3
3x26 3.26x26 K96
3x29 3.29x29 Y99
TM4
4x60 4.60x60 E157
4x61 4.61x61 W158
TM5
5x36 5.36x36 C173
5x40 5.40x40 D177
TM6
6x55 6.55x55 F236
6x59 6.59x59 L240