Structure information

C3a receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8HK2

SPECIES

Homo sapiens

RESOLUTION

2.900

PREFERRED CHAIN

A

REFERENCE

10.1038/S41589-023-01339-W

PUBLICATION DATE

May 10, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
C3a anaphylatoxin W88 23.50x50 ECL1 hydrophobic
C3a anaphylatoxin I102 3.32x32 TM3 hydrophobic
C3a anaphylatoxin R161 4.64x65 TM4 polar (charge-assisted hydrogen bond)
C3a anaphylatoxin F164 ECL2 Van der Waals
C3a anaphylatoxin F164 ECL2 aromatic (edge-to-face)
C3a anaphylatoxin T166 ECL2 Van der Waals
C3a anaphylatoxin D167 ECL2 Van der Waals
C3a anaphylatoxin R171 ECL2 Van der Waals
C3a anaphylatoxin G173 45.51x51 ECL2 Van der Waals
C3a anaphylatoxin Y174 45.52x52 ECL2 Van der Waals
C3a anaphylatoxin Y174 45.52x52 ECL2 polar (hydrogen bond)
C3a anaphylatoxin K175 ECL2 polar (hydrogen bond with backbone)
C3a anaphylatoxin K175 ECL2 Van der Waals
C3a anaphylatoxin R340 5.42x43 TM5 polar (charge-assisted hydrogen bond)
C3a anaphylatoxin Y393 6.51x51 TM6 polar (hydrogen bond with backbone)
C3a anaphylatoxin Y393 6.51x51 TM6 Van der Waals
C3a anaphylatoxin F396 6.54x54 TM6 Van der Waals
C3a anaphylatoxin G397 6.55x55 TM6 Van der Waals
C3a anaphylatoxin G397 6.55x55 TM6 polar (hydrogen bond with backbone)
C3a anaphylatoxin D404 ECL3 polar (charge-assisted hydrogen bond)
C3a anaphylatoxin P405 ECL3 Van der Waals
C3a anaphylatoxin M414 7.32x31 TM7 Van der Waals
C3a anaphylatoxin D417 7.35x34 TM7 polar (charge-assisted hydrogen bond)
C3a anaphylatoxin H418 7.36x35 TM7 Van der Waals
C3a anaphylatoxin H418 7.36x35 TM7 polar (hydrogen bond)
C3a anaphylatoxin I421 7.39x38 TM7 hydrophobic
C3a anaphylatoxin I421 7.39x38 TM7 Van der Waals

Ligands

C3a anaphylatoxin

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Residue Diagrams

G N G P L G L L F T L S L I V M S L I V 1 L H L T L A D L L C C L S L P F S L A H 2 A T L L F V S A F M N L V I I S P I L K 3 A C S I C G C I W V V A F V M C I P V 4 Y C A I M I V S P L L F G V V L R T I T I 5 V V V V A V F L V C W T P Y H I F G V L 6 F P N F C S N A S A L A I C V H D W S 7
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ICL1 M Q R ICL1ECL1 G Q W P Y ECL1ICL2 P I W C Q N H R ICL2ECL2 E I F T T D N H N R C G Y K F G L S S S L D Y P D F Y G D P L E N R S L E N I V Q P P G E M N D R L D P S S F Q T N D H P W T V P T V F Q P Q T F Q R P S A D S L P R G S A R L T S Q N L Y S N V F K P A D V V S P K I P S G F P I E D H E T S P L D N S D A F L S T H L K L F P S A S S N S F Y E S E L P Q G F Q D Y Y N L G Q F T D D D Q ECL2ICL3 G R F A K S Q ICL3ECL3 D P E ECL3N-term M A S F S A E T N S T D L L S Q P W N N-termC-term S I Q G I L E A A F S E E L T R S T H C P S N N V I S E R N S T T V C-term E P P V I L S M V I L S L T F L L G L P G N G L V L W V A G L K T V N T I W F L H L T L A D L L C C L S L P F S L A H L A L Q G R F L C K L I P S I I V L N M F A S V F L L T A I S L D R C L V V F K N V G M A C S I C G C I W V V A F V M C I P V F V Y R V P T P L V A I T I T R L V V G F L L P S V I M I A C Y S F I V F R M Q R S K T F R V A V V V V A V F L V C W T P Y H I F G V L S L L T T P L G K T L M S W D H V C I A L A S A N S C F N P F L Y A L L G K D A R Q F R K K
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Residue Table


GPCRdb(A)
GPCRdb(A)
C3a receptor
ECL1
23x50 23.50x50 W88
TM3
3x32 3.32x32 I102
TM4
4x65 4.64x65 R161
ECL2
45x51 45.51x51 G173
45x52 45.52x52 Y174
TM5
5x43 5.42x43 R340
TM6
6x51 6.51x51 Y393
6x54 6.54x54 F396
6x55 6.55x55 G397
TM7
7x31 7.32x31 M414
7x34 7.35x34 D417
7x35 7.36x35 H418
7x38 7.39x38 I421