Structure information

α1A-adrenoceptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8HN1

SPECIES

Homo sapiens

RESOLUTION

2.900

PREFERRED CHAIN

A

REFERENCE

PUBLICATION DATE

Dec. 20, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
ρ-Da1a F86 2.64x63 TM2 hydrophobic
ρ-Da1a E87 2.65x64 TM2 polar (charge-assisted hydrogen bond)
ρ-Da1a G90 2.68x67 TM2 Van der Waals
ρ-Da1a Y91 23.49x49 ECL1 Van der Waals
ρ-Da1a Y91 23.49x49 ECL1 hydrophobic
ρ-Da1a W102 3.28x28 TM3 Van der Waals
ρ-Da1a W102 3.28x28 TM3 hydrophobic
ρ-Da1a D106 3.32x32 TM3 polar (charge-assisted hydrogen bond)
ρ-Da1a P170 ECL2 Van der Waals
ρ-Da1a D172 ECL2 Van der Waals
ρ-Da1a I175 ECL2 Van der Waals
ρ-Da1a I175 ECL2 hydrophobic
ρ-Da1a C176 45.50x50 ECL2 polar (hydrogen bond with backbone)
ρ-Da1a C176 45.50x50 ECL2 Van der Waals
ρ-Da1a Q177 45.51x51 ECL2 Van der Waals
ρ-Da1a I178 45.52x52 ECL2 Van der Waals
ρ-Da1a I178 45.52x52 ECL2 polar (hydrogen bond with backbone)
ρ-Da1a E180 ECL2 polar (charge-assisted hydrogen bond)
ρ-Da1a P182 5.36x37 TM5 Van der Waals
ρ-Da1a P182 5.36x37 TM5 hydrophobic
ρ-Da1a F297 6.60x60 TM6 hydrophobic
ρ-Da1a F297 6.60x60 TM6 Van der Waals
ρ-Da1a P299 ECL3 Van der Waals
ρ-Da1a P299 ECL3 hydrophobic
ρ-Da1a K302 ECL3 Van der Waals
ρ-Da1a E305 7.32x31 TM7 polar (charge-assisted hydrogen bond)
ρ-Da1a F308 7.35x34 TM7 Van der Waals
ρ-Da1a F308 7.35x34 TM7 hydrophobic
ρ-Da1a K309 7.36x35 TM7 polar (charge-assisted hydrogen bond)
ρ-Da1a F312 7.39x38 TM7 hydrophobic
ρ-Da1a F312 7.39x38 TM7 Van der Waals
ρ-Da1a Y316 7.43x42 TM7 polar (hydrogen bond)

Ligands

ρ-Da1a

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Residue Diagrams

I N G L V G F L I L G G L I V G L L I A 1 V N L A V A D L L L T T S V L P F S A I F 2 I C L G M I S A T C C L V D V A A W I N 3 G L M A L L C V W A L S L V I S I G P L 4 Y M V L I I A L P L Y F S G L A S F L V Y 5 G I V V G C F V L C W L P F F L V M P I 6 I P N I C S N L Y G L W F V I K F V T 7
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ICL1 R H L H ICL1ECL1 Y W A F ECL1ICL2 P L R Y P T I V ICL2ECL2 R Q P A P E D E T I C Q I N E ECL2ICL3 K T D K S D S E Q V T L R I H R K N A P A G G S G M A S A K T K T H F S V R ICL3ECL3 P D F K P ECL3N-term M V F L S G N A S D S S N C T Q P P A N-termC-term I Q C L C R K Q S S K H A L G Y T L H P P S Q A V E G Q H K D M V R I P V G S R E T F Y R I S K T D G V C E W K F F S S M P R G S A R I T V S K D Q S S C T T A R V R S K S F L Q V C C C V G P S T P S L D K N H Q V P T I K V H T I S L S E N G E E V C-term P V N I S K A I L L G V I L G G L I L F G V L G N I L V I L S V A C H S V T H Y Y I V N L A V A D L L L T S T V L P F S A I F E V L G G R V F C N I W A A V D V L C C T A S I M G L C I I S I D R Y I G V S Y T Q R R G L M A L L C V W A L S L V I S I G P L F G W E P G Y V L F S A L G S F Y L P L A I I L V M Y C R V Y V V A K R E S R G L K S G L L L K F S R E K K A A K T L G I V V G C F V L C W L P F F L V M P I G S F F S E T V F K I V F W L G Y L N S C I N P I I Y P C S S Q E F Q N F K K A V L R
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Residue Table


GPCRdb(A)
GPCRdb(A)
α1A-adrenoceptor
TM2
2x63 2.64x63 F86
2x64 2.65x64 E87
2x67 2.68x67 G90
ECL1
23x49 23.49x49 Y91
TM3
3x28 3.28x28 W102
3x32 3.32x32 D106
ECL2
45x50 45.50x50 C176
45x51 45.51x51 Q177
45x52 45.52x52 I178
TM5
5x37 5.36x37 P182
TM6
6x60 6.60x60 F297
TM7
7x31 7.32x31 E305
7x34 7.35x34 F308
7x35 7.36x35 K309
7x38 7.39x38 F312
7x42 7.43x42 Y316