PDB
8HQC
Resolution
3.9 Å
Released
Oct. 18, 2023
Receptor
C5a1
Class
A
Species
Mus musculus
Ligand
[125I]C5a (human)
Function
Agonist
Reference
HTTPS://DOI.ORG/10.1016/J.CELL.2023.09.020

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Ligand Amino Acid Generic Number Segment Interaction Type
[125I]C5a (human) I28 N-term hydrophobic
[125I]C5a (human) H29 N-term polar (hydrogen bond)
[125I]C5a (human) H29 N-term Van der Waals
[125I]C5a (human) L92 2.60x60 TM2 Van der Waals
[125I]C5a (human) L92 2.60x60 TM2 hydrophobic
[125I]C5a (human) N100 ECL1 Van der Waals
[125I]C5a (human) P113 3.29x29 TM3 Van der Waals
[125I]C5a (human) R175 ECL2 Van der Waals
[125I]C5a (human) E176 ECL2 polar (charge-assisted hydrogen bond)
[125I]C5a (human) F181 ECL2 Van der Waals
[125I]C5a (human) Y259 6.51x51 TM6 hydrophobic
[125I]C5a (human) Y259 6.51x51 TM6 Van der Waals
[125I]C5a (human) G263 6.55x55 TM6 Van der Waals
[125I]C5a (human) I266 6.58x58 TM6 Van der Waals
[125I]C5a (human) V287 7.39x38 TM7 Van der Waals
[125I]C5a (human) V287 7.39x38 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 A R R ICL1ECL1 N Y W Y F ECL1ICL2 P I W C Q K V R ICL2ECL2 E A Y K D F Y S E H T V C G I N Y G G G ECL2ICL3 K A T R S ICL3ECL3 P P S ECL3N-term M D P I D N S S F E I N Y D H Y G T M D P N I P A D G I H L P K R N-termC-term L P S I I R N A L S E D S V G R D S K T F T P S T T D T S T R K S Q A V C-term Q P G D V A A L I I Y S V V F L V G V P G N A L V V W V T A F E A V N A I W F L N L A V A D L L S C L A L P V L F T T V L N H D A T A C I V L P S L I L L N M Y A S I L L L A T I S A D R F L L V F K G T G L A W M A C G V A W V L A L L L T I P S F V Y R S F P K E K A V A I L R L M V G F V L P L L T L N I C Y T F L L L R T W S R T K T L K V V M A V V I C F F I F W L P Y Q V T G V M I A W L S P T L K R V E K L N S L C V S L A Y I N C C V N P I I Y V M A G Q G F L R S H G R L
Helix box plot — Download: PNG | SVG A N G P V G V L F V V S Y I I L A A V D 1 L N L A V A D L L S C L A L P V L F T T 2 T A L L L I S A Y M N L L I L S P L V I 3 A W M A C G V A W V L A L L L T I P S 4 Y C I N L T L L P L V F G V M L R L I A V 5 M A V V I C F F I F W L P Y Q V T G V M 6 I P N V C C N I Y A L S V C L S N L K 7

GPCRdb(A)
GPCRdb(A)
C5a1 receptor
TM2
2x60 2.60x60 L92
TM3
3x29 3.29x29 P113
TM6
6x51 6.51x51 Y259
6x55 6.55x55 G263
6x58 6.58x58 I266
TM7
7x38 7.39x38 V287