Structure information

motilin receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8IBV

SPECIES

Homo sapiens

RESOLUTION

3.190

PREFERRED CHAIN

R

REFERENCE

10.1126/SCIADV.ADE9020

PUBLICATION DATE

April 12, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
motilin C30 N-term polar (hydrogen bond with backbone)
motilin C30 N-term polar (hydrogen bond)
motilin S31 N-term Van der Waals
motilin P32 N-term Van der Waals
motilin F33 N-term Van der Waals
motilin S101 ECL1 polar (hydrogen bond)
motilin S101 ECL1 polar (hydrogen bond)
motilin R102 ECL1 Van der Waals
motilin L115 3.29x29 TM3 hydrophobic
motilin L115 3.29x29 TM3 Van der Waals
motilin E119 3.33x33 TM3 polar (charge-assisted hydrogen bond)
motilin E119 3.33x33 TM3 polar (charge-charge)
motilin F173 4.60x61 TM4 Van der Waals
motilin D182 ECL2 polar (charge-charge)
motilin D182 ECL2 polar (charge-assisted hydrogen bond)
motilin S232 ECL2 Van der Waals
motilin E234 ECL2 Van der Waals
motilin C235 45.50x50 ECL2 Van der Waals
motilin R236 45.51x51 ECL2 polar (charge-assisted hydrogen bond)
motilin P237 45.52x52 ECL2 Van der Waals
motilin L245 5.36x37 TM5 Van der Waals
motilin F314 6.51x51 TM6 polar (hydrogen bond)
motilin R318 6.55x55 TM6 polar (charge-assisted hydrogen bond)
motilin Y321 6.58x58 TM6 Van der Waals
motilin Y321 6.58x58 TM6 hydrophobic
motilin T324 6.61x61 TM6 polar (hydrogen bond)
motilin E325 ECL3 Van der Waals
motilin E325 ECL3 polar (hydrogen bond with backbone)
motilin D326 ECL3 polar (charge-assisted hydrogen bond)
motilin D326 ECL3 polar (hydrogen bond with backbone)
motilin S327 7.25x24 TM7 polar (hydrogen bond with backbone)
motilin S327 7.25x24 TM7 polar (hydrogen bond)
motilin M330 7.28x27 TM7 polar (hydrogen bond)
motilin S333 7.31x30 TM7 polar (hydrogen bond)
motilin Q334 7.32x31 TM7 polar (hydrogen bond)
motilin N337 7.35x34 TM7 polar (hydrogen bond)
motilin N337 7.35x34 TM7 polar (hydrogen bond with backbone)
motilin N337 7.35x34 TM7 polar (hydrogen bond)
motilin I338 7.36x35 TM7 Van der Waals
motilin I338 7.36x35 TM7 polar (hydrogen bond with backbone)
motilin A340 7.38x37 TM7 Van der Waals
motilin L341 7.39x38 TM7 Van der Waals
motilin L341 7.39x38 TM7 polar (hydrogen bond with backbone)

Ligands

motilin

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Residue Diagrams

V N G S V G V V F L C L C V A T V P V L 1 G S M A V S D L L I L L G L P F D L Y R 2 A T M H L L T A Y T C G E G V Y L S L R 3 V R A L I A V L W A V A L L S A G P F 4 Y L I S L C L F P L F F Y A T T V W L M V 5 L V V V L A F I I C W L P F H V G R I I 6 I P N I S A S L Y F L Q L A V I N F Y 7
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ICL1 R D M R ICL1ECL1 R P W V F ECL1ICL2 P L R A R V L V ICL2ECL2 G V E Q D P G I S V V P G L N G T A R I A S S P L A S S P P L W L S R A P P P S P P S G P E T A E A A A L F S R E C R P S P A ECL2ICL3 R G P A A ICL3ECL3 E D ECL3N-term M G S P W N G S D G P E G A R E P P W P A L P P C D E R R C S P F N-termC-term S R P R G F H R S R D T A G E V A G D T G G D T V G Y T E T S A N V K T M G C-term P L G A L V P V T A V C L C L F V V G V S G N V V T V M L I G R Y T T T N L Y L G S M A V S D L L I L L G L P F D L Y R L W R S G P L L C R L S L Y V G E G C T Y A T L L H M T A L S V E R Y L A I C R T R R R V R A L I A V L W A V A L L S A G P F L F L V Q L G A L R V M L W V T T A Y F F L P F L C L S I L Y G L I G R E L W S S R R P L S G R E R G H R Q T V R V L L V V V L A F I I C W L P F H V G R I I Y I N T S R M M Y F S Q Y F N I V A L Q L F Y L S A S I N P I L Y N L I S K K A F K R K Y R A A L L L A
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Residue Table


GPCRdb(A)
GPCRdb(A)
motilin receptor
TM3
3x29 3.29x29 L115
3x33 3.33x33 E119
TM4
4x61 4.60x61 F173
ECL2
45x50 45.50x50 C235
45x51 45.51x51 R236
45x52 45.52x52 P237
TM5
5x37 5.36x37 L245
TM6
6x51 6.51x51 F314
6x55 6.55x55 R318
6x58 6.58x58 Y321
6x61 6.61x61 T324
TM7
7x24 7.25x24 S327
7x27 7.28x27 M330
7x30 7.31x30 S333
7x31 7.32x31 Q334
7x34 7.35x34 N337
7x35 7.36x35 I338
7x37 7.38x37 A340
7x38 7.39x38 L341