Structure information

FFA4 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8ID4

SPECIES

Homo sapiens

RESOLUTION

3.100

PREFERRED CHAIN

R

REFERENCE

10.1126/SCIENCE.ADD6220

PUBLICATION DATE

March 15, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
linoleic acid F27 N-term hydrophobic
linoleic acid F88 2.53x53 TM2 hydrophobic
linoleic acid F115 3.29x29 TM3 hydrophobic
linoleic acid M118 3.32x32 TM3 hydrophobic
linoleic acid D208 5.39x40 TM5 polar (charge-assisted hydrogen bond)
linoleic acid F211 5.42x43 TM5 hydrophobic
linoleic acid F211 5.42x43 TM5 Van der Waals
linoleic acid W277 6.48x48 TM6 hydrophobic
linoleic acid I280 6.51x51 TM6 hydrophobic
linoleic acid I280 6.51x51 TM6 Van der Waals
linoleic acid I284 6.55x55 TM6 hydrophobic
linoleic acid I284 6.55x55 TM6 Van der Waals
linoleic acid I287 6.58x58 TM6 Van der Waals
linoleic acid L288 6.59x59 TM6 Van der Waals

Ligands

linoleic acid

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Residue Diagrams

V N G L L S V A F I L V L V T T E V A A 1 L N L F C A D L L F I S A I P L V L A V 2 A A L T L I T V S G S L T M V Y F L L H 3 R A V L L A L I W G Y S A V A A L P L 4 Y S I V I V L G P V L F N L T V F S V D W 5 L F L L M V S F I F M W S P I I I T I L L 6 I P N L A S N A F T F A V V W F F L S 7
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ICL1 R R R G A T ICL1ECL1 E A W L L ECL1ICL2 L Q R G V R G P ICL2ECL2 R V V P Q R L P G A D Q E I S I C T L I W P ECL2ICL3 A Y ICL3ECL3 D L V I ECL3N-term M S P E C A R A A G D A P L R S L E Q A N R T R F P F F S D V K G D N-termC-term P E K G A I L T D T S V K R N D L S I I S G C-term H R L V L A A V E T T V L V L I F A V S L L G N V C A L V L V A R R A C L V L N L F C A D L L F I S A I P L V L A V R W T G P V A C H L L F Y V M T L S G S V T I L T L A A V S L E R M V C I V H G R R A R A V L L A L I W G Y S A V A A L P L C V F F T I P G E I S W D V S F V T L N F L V P G L V I V I S Y S K I L Q I T K A S R K R L T V S L S E S H Q I R V S Q Q D F R L F R T L F L L M V S F F I M W S P I I I T I L L I L I Q N F K Q W P S L F F W V V A F T F A N S A L N P I L Y N M T L C R K I F F N E W K C C F W
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Residue Table


GPCRdb(A)
GPCRdb(A)
FFA4 receptor
TM2
2x53 2.53x53 F88
TM3
3x29 3.29x29 F115
3x32 3.32x32 M118
TM5
5x40 5.39x40 D208
5x43 5.42x43 F211
TM6
6x48 6.48x48 W277
6x51 6.51x51 I280
6x55 6.55x55 I284
6x58 6.58x58 I287
6x59 6.59x59 L288