Structure information

FFA4 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8ID9

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

R

REFERENCE

10.1126/SCIENCE.ADD6220

PUBLICATION DATE

March 15, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
EPA F88 2.53x53 TM2 hydrophobic
EPA F115 3.29x29 TM3 hydrophobic
EPA M118 3.32x32 TM3 hydrophobic
EPA W198 ECL2 hydrophobic
EPA D208 5.39x40 TM5 polar (charge-assisted hydrogen bond)
EPA F211 5.42x43 TM5 hydrophobic
EPA F211 5.42x43 TM5 Van der Waals
EPA W277 6.48x48 TM6 hydrophobic
EPA W277 6.48x48 TM6 Van der Waals
EPA I280 6.51x51 TM6 Van der Waals
EPA I280 6.51x51 TM6 hydrophobic
EPA I284 6.55x55 TM6 polar (hydrogen bond with backbone)
EPA I284 6.55x55 TM6 Van der Waals
EPA I287 6.58x58 TM6 hydrophobic
EPA I287 6.58x58 TM6 Van der Waals
EPA F303 7.35x34 TM7 Van der Waals
EPA F303 7.35x34 TM7 hydrophobic

Ligands

EPA

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Residue Diagrams

V N G L L S V A F I L V L V T T E V A A 1 L N L F C A D L L F I S A I P L V L A V 2 A A L T L I T V S G S L T M V Y F L L H 3 R A V L L A L I W G Y S A V A A L P L 4 Y S I V I V L G P V L F N L T V F S V D W 5 L F L L M V S F I F M W S P I I I T I L L 6 I P N L A S N A F T F A V V W F F L S 7
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ICL1 R R R G A T ICL1ECL1 E A W L L ECL1ICL2 L Q R G V R G P ICL2ECL2 R V V P Q R L P G A D Q E I S I C T L I W P ECL2ICL3 A Y ICL3ECL3 D L V I ECL3N-term M S P E C A R A A G D A P L R S L E Q A N R T R F P F F S D V K G D N-termC-term P E K G A I L T D T S V K R N D L S I I S G C-term H R L V L A A V E T T V L V L I F A V S L L G N V C A L V L V A R R A C L V L N L F C A D L L F I S A I P L V L A V R W T G P V A C H L L F Y V M T L S G S V T I L T L A A V S L E R M V C I V H G R R A R A V L L A L I W G Y S A V A A L P L C V F F T I P G E I S W D V S F V T L N F L V P G L V I V I S Y S K I L Q I T K A S R K R L T V S L S E S H Q I R V S Q Q D F R L F R T L F L L M V S F F I M W S P I I I T I L L I L I Q N F K Q W P S L F F W V V A F T F A N S A L N P I L Y N M T L C R K I F F N E W K C C F W
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Residue Table


GPCRdb(A)
GPCRdb(A)
FFA4 receptor
TM2
2x53 2.53x53 F88
TM3
3x29 3.29x29 F115
3x32 3.32x32 M118
TM5
5x40 5.39x40 D208
5x43 5.42x43 F211
TM6
6x48 6.48x48 W277
6x51 6.51x51 I280
6x55 6.55x55 I284
6x58 6.58x58 I287
TM7
7x34 7.35x34 F303