PDB
8ID9
Resolution
3.0 Å
Released
March 15, 2023
Receptor
FFA4
Class
A
Species
Homo sapiens
Ligand
Function
EPA
Agonist
Reference
10.1126/SCIENCE.ADD6220

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Ligand Amino Acid Generic Number Segment Interaction Type
EPA F27 N-term Van der Waals
EPA F88 2.53x53 TM2 hydrophobic
EPA F115 3.29x29 TM3 hydrophobic
EPA M118 3.32x32 TM3 hydrophobic
EPA T119 3.33x33 TM3 Van der Waals
EPA G122 3.36x36 TM3 Van der Waals
EPA I126 3.40x40 TM3 hydrophobic
EPA L173 4.60x61 TM4 Van der Waals
EPA W198 ECL2 hydrophobic
EPA D208 5.39x40 TM5 polar (hydrogen bond)
EPA F211 5.42x43 TM5 hydrophobic
EPA N215 5.46x461 TM5 hydrophobic
EPA W277 6.48x48 TM6 hydrophobic
EPA I280 6.51x51 TM6 hydrophobic
EPA I281 6.52x52 TM6 hydrophobic
EPA I284 6.55x55 TM6 hydrophobic
EPA I287 6.58x58 TM6 hydrophobic
EPA F303 7.35x34 TM7 hydrophobic
EPA T310 7.42x41 TM7 hydrophobic

EPA

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Snake plot — Download: PNG | SVG
ICL1 R R R G A T ICL1ECL1 E A W L L ECL1ICL2 L Q R G V R G P ICL2ECL2 R V V P Q R L P G A D Q E I S I C T L I W P ECL2ICL3 A Y ICL3ECL3 D L V I ECL3N-term M S P E C A R A A G D A P L R S L E Q A N R T R F P F F S D V K G D N-termC-term P E K G A I L T D T S V K R N D L S I I S G C-term H R L V L A A V E T T V L V L I F A V S L L G N V C A L V L V A R R A C L V L N L F C A D L L F I S A I P L V L A V R W T G P V A C H L L F Y V M T L S G S V T I L T L A A V S L E R M V C I V H G R R A R A V L L A L I W G Y S A V A A L P L C V F F T I P G E I S W D V S F V T L N F L V P G L V I V I S Y S K I L Q I T K A S R K R L T V S L S E S H Q I R V S Q Q D F R L F R T L F L L M V S F F I M W S P I I I T I L L I L I Q N F K Q W P S L F F W V V A F T F A N S A L N P I L Y N M T L C R K I F F N E W K C C F W
Helix box plot — Download: PNG | SVG V N G L L S V A F I L V L V T T E V A A 1 L N L F C A D L L F I S A I P L V L A V 2 A A L T L I T V S G S L T M V Y F L L H 3 R A V L L A L I W G Y S A V A A L P L 4 Y S I V I V L G P V L F N L T V F S V D W 5 L F L L M V S F I F M W S P I I I T I L L 6 I P N L A S N A F T F A V V W F F L S 7

GPCRdb(A)
GPCRdb(A)
FFA4 receptor
TM2
2x53 2.53x53 F88
TM3
3x29 3.29x29 F115
3x32 3.32x32 M118
3x33 3.33x33 T119
3x36 3.36x36 G122
3x40 3.40x40 I126
TM4
4x61 4.60x61 L173
TM5
5x40 5.39x40 D208
5x43 5.42x43 F211
5x461 5.46x461 N215
TM6
6x48 6.48x48 W277
6x51 6.51x51 I280
6x52 6.52x52 I281
6x55 6.55x55 I284
6x58 6.58x58 I287
TM7
7x34 7.35x34 F303
7x41 7.42x41 T310