Structure information

FP receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8IUK

SPECIES

Homo sapiens

RESOLUTION

2.670

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-023-38411-X

PUBLICATION DATE

July 12, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
PGF<sub>2&alpha;</sub> S33 1.39x39 TM1 polar (hydrogen bond)
PGF<sub>2&alpha;</sub> S33 1.39x39 TM1 Van der Waals
PGF<sub>2&alpha;</sub> F36 1.42x42 TM1 Van der Waals
PGF<sub>2&alpha;</sub> H81 2.54x54 TM2 Van der Waals
PGF<sub>2&alpha;</sub> H81 2.54x54 TM2 polar (hydrogen bond)
PGF<sub>2&alpha;</sub> N84 2.57x57 TM2 polar (hydrogen bond with backbone)
PGF<sub>2&alpha;</sub> N84 2.57x57 TM2 Van der Waals
PGF<sub>2&alpha;</sub> G85 2.58x58 TM2 Van der Waals
PGF<sub>2&alpha;</sub> M115 3.32x32 TM3 hydrophobic
PGF<sub>2&alpha;</sub> M115 3.32x32 TM3 Van der Waals
PGF<sub>2&alpha;</sub> S118 3.35x35 TM3 Van der Waals
PGF<sub>2&alpha;</sub> G119 3.36x36 TM3 Van der Waals
PGF<sub>2&alpha;</sub> W185 ECL2 hydrophobic
PGF<sub>2&alpha;</sub> W262 6.48x48 TM6 Van der Waals
PGF<sub>2&alpha;</sub> W262 6.48x48 TM6 hydrophobic
PGF<sub>2&alpha;</sub> L287 7.36x35 TM7 Van der Waals
PGF<sub>2&alpha;</sub> L290 7.39x38 TM7 hydrophobic
PGF<sub>2&alpha;</sub> L290 7.39x38 TM7 Van der Waals
PGF<sub>2&alpha;</sub> R291 7.40x39 TM7 polar (charge-assisted hydrogen bond)
PGF<sub>2&alpha;</sub> A293 7.42x41 TM7 hydrophobic
PGF<sub>2&alpha;</sub> T294 7.43x42 TM7 polar (hydrogen bond)
PGF<sub>2&alpha;</sub> T294 7.43x42 TM7 Van der Waals
PGF<sub>2&alpha;</sub> Q297 7.46x46 TM7 Van der Waals

Ligands

PGF<sub>2&alpha;</sub>

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Residue Diagrams

S N S L I G V T M F I V S F F V 1 S G L V I T D F F G H L I N G A I A V F 2 V S G L L L P C L G S F V M C I G F I S 3 V K M M L S G V C L F A V F I A L L P I 4 I A N C L L S V G L A L L G L F S F L L 5 L A I M C V S C I C W S P F L V T M A N 6 W P D L I Q N W T A M R L A F L T T E 7
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ICL1 K S K ICL1ECL1 K E W I R F D Q S ECL1ICL2 P I F H S T K I ICL2ECL2 H R D Y K I Q A S R T W C F Y N T E D I K ECL2ICL3 Q H R Q G ICL3ECL3 G N H S L E ECL3N-term M S M N N S K Q L V S P A A A L L S N T T C Q T E N R L S N-termC-term I S L H I W E L S S I K N S L K V A A I S E S P V A E K S A S T C-term V F F S V I F M T V G I L S N S L A I A I L M K A Y Q R F R Q A S F L L L A S G L V I T D F F G H L I N G A I A V F V Y A S D N V L C S I F G I C M V F S G L C P L L L G S V M A I E R C I G V T K T S K H V K M M L S G V C L F A V F I A L L P I L G D W E D R F Y L L L F S F L G L L A L G V S L L C N A I T G I T L L R V K F K S Q R S H H L E M V I Q L L A I M C V S C I C W S P F L V T M A N I G I N T C E T T L F A L R M A T W N Q I L D P W V Y I L L R K A L Y K C C G V L K N L A S Q V H V
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Residue Table


GPCRdb(A)
GPCRdb(A)
FP receptor
TM1
1x39 1.39x39 S33
1x42 1.42x42 F36
TM2
2x54 2.54x54 H81
2x57 2.57x57 N84
2x58 2.58x58 G85
TM3
3x32 3.32x32 M115
3x35 3.35x35 S118
3x36 3.36x36 G119
TM6
6x48 6.48x48 W262
TM7
7x35 7.36x35 L287
7x38 7.39x38 L290
7x39 7.40x39 R291
7x41 7.42x41 A293
7x42 7.43x42 T294
7x46 7.46x46 Q297