Structure information
FP receptorPROTEIN CLASS
Class A (Rhodopsin)
PDB CODE
8IUL
SPECIES
Homo sapiens
RESOLUTION
2.780
PREFERRED CHAIN
R
REFERENCEPUBLICATION DATE
July 12, 2023
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Ligand Interaction Browser
Download list in excel| Ligand | Amino Acid | Generic Number | Segment | Interaction Type |
|---|---|---|---|---|
| Ligand | Amino Acid | Generic Number | Segment | Interaction Type |
| latanoprost (free acid form) | S33 | 1.39x39 | TM1 | polar (hydrogen bond with backbone) |
| latanoprost (free acid form) | S33 | 1.39x39 | TM1 | Van der Waals |
| latanoprost (free acid form) | S33 | 1.39x39 | TM1 | polar (hydrogen bond) |
| latanoprost (free acid form) | F36 | 1.42x42 | TM1 | Van der Waals |
| latanoprost (free acid form) | M37 | 1.43x43 | TM1 | Van der Waals |
| latanoprost (free acid form) | M37 | 1.43x43 | TM1 | hydrophobic |
| latanoprost (free acid form) | H81 | 2.54x54 | TM2 | polar (hydrogen bond) |
| latanoprost (free acid form) | H81 | 2.54x54 | TM2 | Van der Waals |
| latanoprost (free acid form) | N84 | 2.57x57 | TM2 | Van der Waals |
| latanoprost (free acid form) | G85 | 2.58x58 | TM2 | Van der Waals |
| latanoprost (free acid form) | A88 | 2.61x61 | TM2 | Van der Waals |
| latanoprost (free acid form) | Y92 | 2.65x65 | TM2 | polar (hydrogen bond) |
| latanoprost (free acid form) | Y92 | 2.65x65 | TM2 | Van der Waals |
| latanoprost (free acid form) | F111 | 3.28x28 | TM3 | hydrophobic |
| latanoprost (free acid form) | F111 | 3.28x28 | TM3 | Van der Waals |
| latanoprost (free acid form) | M115 | 3.32x32 | TM3 | Van der Waals |
| latanoprost (free acid form) | M115 | 3.32x32 | TM3 | hydrophobic |
| latanoprost (free acid form) | S118 | 3.35x35 | TM3 | polar (hydrogen bond) |
| latanoprost (free acid form) | S118 | 3.35x35 | TM3 | Van der Waals |
| latanoprost (free acid form) | G119 | 3.36x36 | TM3 | Van der Waals |
| latanoprost (free acid form) | T184 | ECL2 | polar (hydrogen bond) | |
| latanoprost (free acid form) | T184 | ECL2 | Van der Waals | |
| latanoprost (free acid form) | W185 | ECL2 | Van der Waals | |
| latanoprost (free acid form) | W185 | ECL2 | hydrophobic | |
| latanoprost (free acid form) | F187 | 45.51x51 | ECL2 | hydrophobic |
| latanoprost (free acid form) | F187 | 45.51x51 | ECL2 | Van der Waals |
| latanoprost (free acid form) | W262 | 6.48x48 | TM6 | Van der Waals |
| latanoprost (free acid form) | W262 | 6.48x48 | TM6 | hydrophobic |
| latanoprost (free acid form) | F265 | 6.51x51 | TM6 | aromatic (face-to-edge) |
| latanoprost (free acid form) | F265 | 6.51x51 | TM6 | Van der Waals |
| latanoprost (free acid form) | L287 | 7.36x35 | TM7 | Van der Waals |
| latanoprost (free acid form) | L290 | 7.39x38 | TM7 | hydrophobic |
| latanoprost (free acid form) | L290 | 7.39x38 | TM7 | Van der Waals |
| latanoprost (free acid form) | R291 | 7.40x39 | TM7 | polar (charge-assisted hydrogen bond) |
| latanoprost (free acid form) | T294 | 7.43x42 | TM7 | polar (hydrogen bond) |
| latanoprost (free acid form) | T294 | 7.43x42 | TM7 | Van der Waals |
| latanoprost (free acid form) | Q297 | 7.46x46 | TM7 | Van der Waals |
Ligands
latanoprost (free acid form)
Residue Diagrams
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Residue Table
|
GPCRdb(A)
|
GPCRdb(A)
|
FP receptor
|
|---|---|---|
| TM1 | ||
| 1x39 | 1.39x39 | S33 |
| 1x42 | 1.42x42 | F36 |
| 1x43 | 1.43x43 | M37 |
| TM2 | ||
| 2x54 | 2.54x54 | H81 |
| 2x57 | 2.57x57 | N84 |
| 2x58 | 2.58x58 | G85 |
| 2x61 | 2.61x61 | A88 |
| 2x65 | 2.65x65 | Y92 |
| TM3 | ||
| 3x28 | 3.28x28 | F111 |
| 3x32 | 3.32x32 | M115 |
| 3x35 | 3.35x35 | S118 |
| 3x36 | 3.36x36 | G119 |
| ECL2 | ||
| 45x51 | 45.51x51 | F187 |
| TM6 | ||
| 6x48 | 6.48x48 | W262 |
| 6x51 | 6.51x51 | F265 |
| TM7 | ||
| 7x35 | 7.36x35 | L287 |
| 7x38 | 7.39x38 | L290 |
| 7x39 | 7.40x39 | R291 |
| 7x42 | 7.43x42 | T294 |
| 7x46 | 7.46x46 | Q297 |