PDB
8J24
Resolution
2.6 Å
Released
Jan. 24, 2024
Receptor
FFA2
Class
A
Species
Homo sapiens
Ligand
Function
acetic acid
Agonist
Reference
10.1038/S41422-023-00914-Z

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Ligand Amino Acid Generic Number Segment Interaction Type
acetic acid Y90 3.33x33 TM3 hydrophobic
acetic acid C141 4.57x57 TM4 Van der Waals
acetic acid I143 4.59x59 TM4 Van der Waals
acetic acid V144 4.60x60 TM4 hydrophobic
acetic acid Y165 45.51x51 ECL2 polar (hydrogen bond)
acetic acid R180 5.39x40 TM5 polar (charge-charge)
acetic acid L183 5.42x43 TM5 hydrophobic
acetic acid Y238 6.51x51 TM6 polar (hydrogen bond)
acetic acid R255 7.34x33 TM7 polar (charge-charge)

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Snake plot — Download: PNG | SVG
ICL1 P Q P ICL1ECL1 N F R W Y L ECL1ICL2 P V Q Y K L S R ICL2ECL2 T E Q V R S G N E I T C Y E N F T D N ECL2ICL3 P L V ICL3ECL3 K S P W ECL3N-term M L N-termC-term R N Q G S S L L G R R G K D T A E G T N E D R G V G Q G E G M P S S D F T T E C-term P D W K S S L I L M A Y I I I F L T G L P A N L L A L R A F V G R I R Q A P V H I L L L S L T L A D L L L L L L L P F K I I E A A S P K V V C A L T S F G F Y S S I Y C S T W L L A G I S I E R Y L G V A F R P L Y G V I A A L V A W V M S F G H C T I V I I V Q Y L N T Q L D V V L P V R L E L C L V L F F I P M A V T I F C Y W R F V W I M L S Q G A Q R R R R A V G L A V V T L L N F L V C F G P Y N V S H L V G Y H Q R W R S I A V V F S S L N A S L D P L L F Y F S S S V F G R L V R R A G L Q V
Helix box plot — Download: PNG | SVG L N A P L G T L F I I I Y A M L I L S S 1 L S L T L A D L L L L L L L P F K I I E 2 G A L L W T S C Y I S S Y F G F S T L A 3 G V I A A L V A W V M S F G H C T I V I 4 Y C F I T V A M P I F F L V L C L E L R V 5 A V V T L L N F V L C F G P Y N V S H L V 6 L P D L S A N L S S F V V A I S R W 7

GPCRdb(A)
GPCRdb(A)
FFA2 receptor
TM3
3x33 3.33x33 Y90
TM4
4x57 4.57x57 C141
4x59 4.59x59 I143
4x60 4.60x60 V144
ECL2
45x51 45.51x51 Y165
TM5
5x40 5.39x40 R180
5x43 5.42x43 L183
TM6
6x51 6.51x51 Y238
TM7
7x33 7.34x33 W254