Structure information

HCA2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8J6J

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

R

REFERENCE

10.1016/J.CELREP.2023.113406

PUBLICATION DATE

Jan. 10, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
GSK256073 L83 2.60x60 TM2 hydrophobic
GSK256073 W91 ECL1 hydrophobic
GSK256073 L104 3.29x29 TM3 hydrophobic
GSK256073 L107 3.32x32 TM3 hydrophobic
GSK256073 A108 3.33x33 TM3 hydrophobic
GSK256073 R111 3.36x36 TM3 polar (charge-assisted hydrogen bond)
GSK256073 L162 4.60x60 TM4 Van der Waals
GSK256073 C177 45.50x50 ECL2 Van der Waals
GSK256073 C177 45.50x50 ECL2 hydrophobic
GSK256073 S178 45.51x51 ECL2 Van der Waals
GSK256073 S179 45.52x52 ECL2 Van der Waals
GSK256073 F180 ECL2 Van der Waals
GSK256073 F180 ECL2 aromatic (edge-to-face)
GSK256073 H189 5.39x40 TM5 Van der Waals
GSK256073 L280 7.39x38 TM7 hydrophobic
GSK256073 L280 7.39x38 TM7 Van der Waals
GSK256073 Y284 7.43x42 TM7 polar (hydrogen bond)
GSK256073 Y284 7.43x42 TM7 polar (hydrogen bond)

Ligands

GSK256073

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Residue Diagrams

G N G L L G F I F E L G L V P P L V K V 1 F N L A V A D F L L I I C L P F L M D N 2 V T L F I I S G Q R N M A L M F L M L R 3 A A I I S C L L W G I T I G L T V H L L 4 S C F L I I G L P L F F E L L F M A E H W 5 M V V A I V F V I C F L P S V V V R I R 6 V P D L M S N M Y T F S L T I F F A L 7
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ICL1 L K S W ICL1ECL1 W D W K F ECL1ICL2 P H H A L N K I ICL2ECL2 M P I Q N G G A N L C S S F S I C H T F ECL2ICL3 M D R H A ICL3ECL3 G T Q N C E V ECL3N-term M N R H H L Q D H F L E I D K K N C C V F R D D N-termC-term Q R K M T G E P D N N R S T S V E L T G D P N K T R G A P E A L M A N S G E P W S P S Y L G P T S P C-term F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F H K S S R I F L F N L A V A D F L L I I C L P F L M D N Y V R R G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H S N R T A A I I S C L L W G I T I G L T V H L L K K K Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T S Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S F S T C L F P N F L I N R
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Residue Table


GPCRdb(A)
GPCRdb(A)
HCA2 receptor
TM2
2x60 2.60x60 L83
TM3
3x29 3.29x29 L104
3x32 3.32x32 L107
3x33 3.33x33 A108
3x36 3.36x36 R111
TM4
4x60 4.60x60 L162
ECL2
45x50 45.50x50 C177
45x51 45.51x51 S178
45x52 45.52x52 S179
TM5
5x40 5.39x40 H189
TM7
7x38 7.39x38 L280
7x42 7.43x42 Y284