Structure information

NK3 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8JBF

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

B

REFERENCE

10.1038/S41421-023-00564-W

PUBLICATION DATE

Feb. 28, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
senktide Q77 N-term polar (hydrogen bond)
senktide Q77 N-term Van der Waals
senktide F78 N-term Van der Waals
senktide F78 N-term hydrophobic
senktide N138 2.57x57 TM2 polar (hydrogen bond)
senktide N138 2.57x57 TM2 Van der Waals
senktide N138 2.57x57 TM2 polar (hydrogen bond)
senktide N142 2.61x61 TM2 polar (hydrogen bond)
senktide Y145 2.64x64 TM2 Van der Waals
senktide Y145 2.64x64 TM2 polar (hydrogen bond)
senktide A146 2.65x65 TM2 Van der Waals
senktide A146 2.65x65 TM2 hydrophobic
senktide N162 3.29x29 TM3 Van der Waals
senktide I166 3.33x33 TM3 hydrophobic
senktide I166 3.33x33 TM3 Van der Waals
senktide F170 3.37x37 TM3 Van der Waals
senktide Q218 4.60x61 TM4 polar (hydrogen bond)
senktide L232 ECL2 Van der Waals
senktide L232 ECL2 hydrophobic
senktide F234 45.51x51 ECL2 hydrophobic
senktide F234 45.51x51 ECL2 Van der Waals
senktide V235 45.52x52 ECL2 hydrophobic
senktide V235 45.52x52 ECL2 Van der Waals
senktide Q236 ECL2 Van der Waals
senktide H248 5.39x40 TM5 polar (hydrogen bond)
senktide Y315 6.51x51 TM6 Van der Waals
senktide Y315 6.51x51 TM6 polar (hydrogen bond)
senktide Y318 6.54x54 TM6 Van der Waals
senktide F319 6.55x55 TM6 Van der Waals
senktide F319 6.55x55 TM6 hydrophobic
senktide N329 ECL3 Van der Waals
senktide N329 ECL3 polar (hydrogen bond)
senktide R330 ECL3 polar (charge-assisted hydrogen bond)
senktide I334 7.31x30 TM7 hydrophobic
senktide I334 7.31x30 TM7 Van der Waals
senktide Y338 7.35x34 TM7 aromatic (face-to-edge)
senktide Y338 7.35x34 TM7 polar (hydrogen bond)
senktide Y338 7.35x34 TM7 Van der Waals
senktide F342 7.39x38 TM7 Van der Waals

Ligands

senktide

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Residue Diagrams

L N G L V A V A V V V G Y A L S W L A I 1 V N L A F S D A S M A A F N T L V N F I 2 A T M S Y I S A F V A T I P F F N Q F R 3 T K I V I G S I W I L A F L L A F P Q 4 Y T I G M I L L P F C Y V L I I V I I H Y 5 I I V V M T F A I C W L P Y H I Y F I L 6 I P N Y M T S S M A L W F S A L Y V Q 7
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ICL1 K R M R ICL1ECL1 E W Y F ECL1ICL2 P L K P R L ICL2ECL2 K T K V M P G R T L C F V Q W P E ECL2ICL3 T C D ICL3ECL3 Q Q L N R W ECL3N-term M A T L P A A E T W I D G G G G V G A D A V N L T A S L A A G A A T G A V E T G W L Q L L D Q A G N L S S S P S A L G L P V A S P A P S Q P W A N L T N Q F V Q N-termC-term R W C P F I K V S S Y D E L E L K T T R F H P N R Q S S M Y T V T R M E S M T V V F D P N D A D T T R S S R K K R A T P R D P S F N G C S R R N S K S A S A T S S F I S S P Y T S V D E Y S C-term P S W R I A L W S L A Y G V V V A V A V L G N L I V I W I I L A H T V T N Y F L V N L A F S D A S M A A F N T L V N F I Y A L H S G A N Y C R F Q N F F P I T A V F A S I Y S M T A I A V D R Y M A I I D S A T A T K I V I G S I W I L A F L L A F P Q C L Y S G P K Q H F T Y H I I V I I L V Y C F P L L I M G I T Y T I V G I T L W G G E I P G D K Y H E Q L K A K R K V V K M M I I V V M T F A I C W L P Y H I Y F I L T A I Y K Y I Q Q V Y L A S F W L A M S S T M Y N P I I Y C C L N K R F K R F R A G A F
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Residue Table


GPCRdb(A)
GPCRdb(A)
NK3 receptor
TM2
2x57 2.57x57 N138
2x61 2.61x61 N142
2x64 2.64x64 Y145
2x65 2.65x65 A146
TM3
3x29 3.29x29 N162
3x33 3.33x33 I166
3x37 3.37x37 F170
TM4
4x61 4.60x61 Q218
ECL2
45x51 45.51x51 F234
45x52 45.52x52 V235
TM5
5x40 5.39x40 H248
TM6
6x51 6.51x51 Y315
6x54 6.54x54 Y318
6x55 6.55x55 F319
TM7
7x30 7.31x30 I334
7x34 7.35x34 Y338
7x38 7.39x38 F342