Structure information

mGlu2 receptor

PROTEIN CLASS

Class C (Glutamate)

PDB CODE

8JD0

SPECIES

Homo sapiens

RESOLUTION

3.300

PREFERRED CHAIN

2

REFERENCE

10.1038/S41422-023-00830-2

PUBLICATION DATE

June 21, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL3894759 L639 3.36x36 TM3 polar (hydrogen bond with backbone)
CHEMBL3894759 L639 3.36x36 TM3 Van der Waals
CHEMBL3894759 G640 3.37x37 TM3 Van der Waals
CHEMBL3894759 F643 3.40x40 TM3 hydrophobic
CHEMBL3894759 F643 3.40x40 TM3 Van der Waals
CHEMBL3894759 D725 5.37x37 TM5 Van der Waals
CHEMBL3894759 S731 5.43x43 TM5 Van der Waals
CHEMBL3894759 N735 5.47x47 TM5 polar (hydrogen bond)
CHEMBL3894759 N735 5.47x47 TM5 polar (hydrogen bond)
CHEMBL3894759 N735 5.47x47 TM5 polar (hydrogen bond)
CHEMBL3894759 T769 6.46x46 TM6 Van der Waals
CHEMBL3894759 F780 6.57x57 TM6 hydrophobic
CHEMBL3894759 F780 6.57x57 TM6 Van der Waals
CHEMBL3894759 M794 7.32x33 TM7 Van der Waals

Ligands

CHEMBL3894759

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Residue Diagrams

L T A L A G L C A I T V P G V A W A D G 1 Y I L L G G V F L C Y C M T F I F I A 2 T L L A S Y C V S F A T G L G L R R L T 3 Q V A I C L A L I S G Q L L I V V A W L 4 A Y L T C L A I L L V N Y A L S G L M S 5 G F T M Y T T C I I W L A F L P I F Y V 6 G L V V S G S L S V S V C M T T T Q V R 7
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ICL1 T N A P V V K A S ICL1ECL1 K P ECL1ICL2 A R E G A Q R P R F I ICL2ECL2 A P G T G K E T A P E R R E V V T L R C N H R ECL2ICL3 P E N ICL3ECL3 S ECL3N-term M G S L L A L L A L L L L W G A V A E G P A K K V L T L E G D L V L G G L F P V H Q K G G P A E D C G P V N E H R G I Q R L E A M L F A L D R I N R D P H L L P G V R L G A H I L D S C S K D T H A L E Q A L D F V R A S L S R G A D G S R H I C P D G S Y A T H G D A P T A I T G V I G G S Y S D V S I Q V A N L L R L F Q I P Q I S Y A S T S A K L S D K S R Y D Y F A R T V P P D F F Q A K A M A E I L R F F N W T Y V S T V A S E G D Y G E T G I E A F E L E A R A R N I C V A T S E K V G R A M S R A A F E G V V R A L L Q K P S A R V A V L F T R S E D A R E L L A A S Q R L N A S F T W V A S D G W G A L E S V V A G S E G A A E G A I T I E L A S Y P I S D F A S Y F Q S L D P W N N S R N P W F R E F W E Q R F R C S F R Q R D C A A H S L R A V P F E Q E S K I M F V V N A V Y A M A H A L H N M H R A L C P N T T R L C D A M R P V N G R R L Y K D F V L N V K F D A P F R P A D T H N E V R F D R F G D G I G R Y N I F T Y L R A G S G R Y R Y Q K V G Y W A E G L T L D T S L I P W A S P S A G P L P A S R C S E P C L Q N E V K S V Q P G E V C C W L C I P C Q P Y E Y R L D E F T C A D C G L G Y W P N A S L T G C F E L P Q E Y I R W N-termC-term S R F G S A A A R A S S S L G Q G S G S Q F V P T V C N G R E V V D S T T S S L C-term G D A W A V G P V T I A C L G A L A T L F V L G V F V R H G R E L C Y I L L G G V F L C Y C M T F I F I A S T A V C T L R R L G L G T A F S V C Y S A L L T K T N R I A R I F G G S P A S Q V A I C L A L I S G Q L L I V V A W L V V E D A S M L G S L A Y N V L L I A L C T L Y A F K T R K C F N E A K F I G F T M Y T T C I I W L A F L P I F Y V T S D Y R V Q T T T M C V S V S L S G S V V L G C L F A P K L H I I L F Q P Q K H R A N V V S P T
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Residue Table


GPCRdb(A)
GPCRdb(C)
mGlu2 receptor
TM3
3x32 3.36x36 L639
3x33 3.37x37 G640
3x36 3.40x40 F643
TM5
5x37 5.37x37 D725
5x43 5.43x43 S731
5x47 5.47x47 N735
TM6
6x44 6.46x46 T769
6x55 6.57x57 F780
TM7
7x38 7.32x33 M794