Structure information

mGlu2 receptor

PROTEIN CLASS

Class C (Glutamate)

PDB CODE

8JD5

SPECIES

Homo sapiens

RESOLUTION

3.600

PREFERRED CHAIN

2

REFERENCE

10.1038/S41422-023-00830-2

PUBLICATION DATE

June 21, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
JNJ-40411813 L639 3.36x36 TM3 hydrophobic
JNJ-40411813 F643 3.40x40 TM3 hydrophobic
JNJ-40411813 Y647 3.44x44 TM3 hydrophobic
JNJ-40411813 M728 5.40x40 TM5 hydrophobic
JNJ-40411813 L732 5.44x44 TM5 hydrophobic
JNJ-40411813 N735 5.47x47 TM5 polar (hydrogen bond)
JNJ-40411813 N735 5.47x47 TM5 Van der Waals
JNJ-40411813 I739 5.51x51 TM5 Van der Waals
JNJ-40411813 I739 5.51x51 TM5 hydrophobic
JNJ-40411813 T769 6.46x46 TM6 Van der Waals
JNJ-40411813 W773 6.50x50 TM6 Van der Waals
JNJ-40411813 W773 6.50x50 TM6 hydrophobic
JNJ-40411813 L777 6.54x54 TM6 hydrophobic
JNJ-40411813 L777 6.54x54 TM6 Van der Waals
JNJ-40411813 F780 6.57x57 TM6 hydrophobic
JNJ-40411813 F780 6.57x57 TM6 Van der Waals
JNJ-40411813 Y781 6.58x58 TM6 Van der Waals
JNJ-40411813 Y781 6.58x58 TM6 aromatic (face-to-edge)

Ligands

JNJ-40411813

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Residue Diagrams

L T A L A G L C A I T V P G V A W A D G 1 Y I L L G G V F L C Y C M T F I F I A 2 T L L A S Y C V S F A T G L G L R R L T 3 Q V A I C L A L I S G Q L L I V V A W L 4 A Y L T C L A I L L V N Y A L S G L M S 5 G F T M Y T T C I I W L A F L P I F Y V 6 G L V V S G S L S V S V C M T T T Q V R 7
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ICL1 T N A P V V K A S ICL1ECL1 K P ECL1ICL2 A R E G A Q R P R F I ICL2ECL2 A P G T G K E T A P E R R E V V T L R C N H R ECL2ICL3 P E N ICL3ECL3 S ECL3N-term M G S L L A L L A L L L L W G A V A E G P A K K V L T L E G D L V L G G L F P V H Q K G G P A E D C G P V N E H R G I Q R L E A M L F A L D R I N R D P H L L P G V R L G A H I L D S C S K D T H A L E Q A L D F V R A S L S R G A D G S R H I C P D G S Y A T H G D A P T A I T G V I G G S Y S D V S I Q V A N L L R L F Q I P Q I S Y A S T S A K L S D K S R Y D Y F A R T V P P D F F Q A K A M A E I L R F F N W T Y V S T V A S E G D Y G E T G I E A F E L E A R A R N I C V A T S E K V G R A M S R A A F E G V V R A L L Q K P S A R V A V L F T R S E D A R E L L A A S Q R L N A S F T W V A S D G W G A L E S V V A G S E G A A E G A I T I E L A S Y P I S D F A S Y F Q S L D P W N N S R N P W F R E F W E Q R F R C S F R Q R D C A A H S L R A V P F E Q E S K I M F V V N A V Y A M A H A L H N M H R A L C P N T T R L C D A M R P V N G R R L Y K D F V L N V K F D A P F R P A D T H N E V R F D R F G D G I G R Y N I F T Y L R A G S G R Y R Y Q K V G Y W A E G L T L D T S L I P W A S P S A G P L P A S R C S E P C L Q N E V K S V Q P G E V C C W L C I P C Q P Y E Y R L D E F T C A D C G L G Y W P N A S L T G C F E L P Q E Y I R W N-termC-term S R F G S A A A R A S S S L G Q G S G S Q F V P T V C N G R E V V D S T T S S L C-term G D A W A V G P V T I A C L G A L A T L F V L G V F V R H G R E L C Y I L L G G V F L C Y C M T F I F I A S T A V C T L R R L G L G T A F S V C Y S A L L T K T N R I A R I F G G S P A S Q V A I C L A L I S G Q L L I V V A W L V V E D A S M L G S L A Y N V L L I A L C T L Y A F K T R K C F N E A K F I G F T M Y T T C I I W L A F L P I F Y V T S D Y R V Q T T T M C V S V S L S G S V V L G C L F A P K L H I I L F Q P Q K H R A N V V S P T
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Residue Table


GPCRdb(A)
GPCRdb(C)
mGlu2 receptor
TM3
3x32 3.36x36 L639
3x36 3.40x40 F643
3x40 3.44x44 Y647
TM5
5x40 5.40x40 M728
5x44 5.44x44 L732
5x47 5.47x47 N735
5x51 5.51x51 I739
TM6
6x44 6.46x46 T769
6x48 6.50x50 W773
6x52 6.54x54 L777
6x55 6.57x57 F780
6x56 6.58x58 Y781