Structure information

HCA2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8JER

SPECIES

Homo sapiens

RESOLUTION

3.450

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-024-46239-2

PUBLICATION DATE

March 6, 2024

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Ligand Interaction Browser

Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
5-Methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid L104 3.29x29 TM3 hydrophobic
5-Methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid S179 45.52x52 ECL2 polar (hydrogen bond with backbone)
5-Methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid S179 45.52x52 ECL2 polar (hydrogen bond)
5-Methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid F180 ECL2 polar (hydrogen bond with backbone)
5-Methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid F180 ECL2 Van der Waals
5-Methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid F277 7.36x35 TM7 hydrophobic
5-Methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid F277 7.36x35 TM7 Van der Waals
5-Methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid L280 7.39x38 TM7 Van der Waals
5-Methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid L280 7.39x38 TM7 hydrophobic
5-Methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid Y284 7.43x42 TM7 Van der Waals
5-Methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid Y284 7.43x42 TM7 polar (hydrogen bond)

Ligands

5-Methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid

3D interaction viewer Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.


Residue Diagrams

G N G L L G F I F E L G L V P P L V K V 1 F N L A V A D F L L I I C L P F L M D N 2 V T L F I I S G Q R N M A L M F L M L R 3 A A I I S C L L W G I T I G L T V H L L 4 S C F L I I G L P L F F E L L F M A E H W 5 M V V A I V F V I C F L P S V V V R I R 6 V P D L M S N M Y T F S L T I F F A L 7
Download: PNG | SVG
ICL1 L K S W ICL1ECL1 W D W K F ECL1ICL2 P H H A L N K I ICL2ECL2 M P I Q N G G A N L C S S F S I C H T F ECL2ICL3 M D R H A ICL3ECL3 G T Q N C E V ECL3N-term M N R H H L Q D H F L E I D K K N C C V F R D D N-termC-term Q R K M T G E P D N N R S T S V E L T G D P N K T R G A P E A L M A N S G E P W S P S Y L G P T S P C-term F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F H K S S R I F L F N L A V A D F L L I I C L P F L M D N Y V R R G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H S N R T A A I I S C L L W G I T I G L T V H L L K K K Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T S Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S F S T C L F P N F L I N R
Download: PNG | SVG

Residue Table


GPCRdb(A)
GPCRdb(A)
HCA2 receptor
TM3
3x29 3.29x29 L104
ECL2
45x52 45.52x52 S179
TM7
7x35 7.36x35 F277
7x38 7.39x38 L280
7x42 7.43x42 Y284