Structure information

MRGPRX1

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8JGG

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-023-40705-Z

PUBLICATION DATE

Jan. 10, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
bovine adrenal medulla peptide 8-22 Y99 3.29x29 TM3 hydrophobic
bovine adrenal medulla peptide 8-22 E157 4.60x60 TM4 polar (hydrogen bond with backbone)
bovine adrenal medulla peptide 8-22 E157 4.60x60 TM4 polar (charge-assisted hydrogen bond)
bovine adrenal medulla peptide 8-22 W158 4.61x61 TM4 aromatic (edge-to-face)
bovine adrenal medulla peptide 8-22 W158 4.61x61 TM4 polar (hydrogen bond with backbone)
bovine adrenal medulla peptide 8-22 W158 4.61x61 TM4 Van der Waals
bovine adrenal medulla peptide 8-22 D177 5.40x40 TM5 polar (charge-assisted hydrogen bond)
bovine adrenal medulla peptide 8-22 F236 6.55x55 TM6 Van der Waals
bovine adrenal medulla peptide 8-22 F237 6.56x56 TM6 Van der Waals
bovine adrenal medulla peptide 8-22 L240 6.59x59 TM6 polar (hydrogen bond with backbone)
bovine adrenal medulla peptide 8-22 L240 6.59x59 TM6 Van der Waals
bovine adrenal medulla peptide 8-22 W241 6.60x60 TM6 Van der Waals
bovine adrenal medulla peptide 8-22 W241 6.60x60 TM6 aromatic (face-to-edge)
bovine adrenal medulla peptide 8-22 I242 ECL3 Van der Waals
bovine adrenal medulla peptide 8-22 H243 ECL3 Van der Waals
bovine adrenal medulla peptide 8-22 L249 7.30x29 TM7 hydrophobic
bovine adrenal medulla peptide 8-22 L249 7.30x29 TM7 Van der Waals
bovine adrenal medulla peptide 8-22 F250 7.31x30 TM7 aromatic (face-to-face)
bovine adrenal medulla peptide 8-22 F250 7.31x30 TM7 Van der Waals
bovine adrenal medulla peptide 8-22 H254 7.35x34 TM7 Van der Waals

Ligands

bovine adrenal medulla peptide 8-22

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Residue Diagrams

A N G T L G V L S V I C T L V T L S L T 1 L N L A A A D F L F L S G R L I Y S L L 2 A S L F S L G A F Y S F M M V P Y L I K 3 S A V V C V L L W A L S L L R S I L E W 4 S S G C L V V C L F I L W A V T I F D S 5 L L T V L V F L L C G L P F G I Q F F L 6 I P N A S S N L A S L F I S V L H V H 7
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ICL1 R R ICL1ECL1 S I P H T ECL1ICL2 P I W Y R C H R ICL2ECL2 G F L F S G A ECL2ICL3 G S R K I ICL3ECL3 V D R E V ECL3N-term M D P T I S T L D T E L T P I N G T E E T L C Y K N-termC-term Q R Q N R Q N L K L V L Q R A L Q D A S E V D E G G G Q L P E E I L E L S G S R L E Q C-term Q T L S L T V L T C I V S L V G L T G N A V V L W L L G C R M N A F S I Y I L N L A A A D F L F L S G R L I Y S L L S F I I S K I L Y P V M M F S Y F A G L S F L S A V S T E R C L S V L W P T H L S A V V C V L L W A L S L L R S I L E W M L C D S A W C Q T S D F I T V A W L I F L C V V L C G S S L V L L I R I L C P L T R L Y V T I L L T V L V F L L C G L P F G I Q F F L F L W I H L F C H V H L V S I F L S A L N S S A N P I I Y F F V G S F R
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Residue Table


GPCRdb(A)
GPCRdb(A)
MRGPRX1
TM3
3x29 3.29x29 Y99
TM4
4x60 4.60x60 E157
4x61 4.61x61 W158
TM5
5x40 5.40x40 D177
TM6
6x55 6.55x55 F236
6x56 6.56x56 F237
6x59 6.59x59 L240
6x60 6.60x60 W241
TM7
7x29 7.30x29 L249
7x30 7.31x30 F250
7x34 7.35x34 H254