Structure information

β2-adrenoceptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8JJ8

SPECIES

Homo sapiens

RESOLUTION

3.200

PREFERRED CHAIN

F

REFERENCE

10.1038/S41589-023-01389-0

PUBLICATION DATE

Sept. 6, 2023

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Ligand Interaction Browser

Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
ARFORMOTEROL W109 3.28x28 TM3 hydrophobic
ARFORMOTEROL D113 3.32x32 TM3 polar (charge-assisted hydrogen bond)
ARFORMOTEROL V114 3.33x33 TM3 hydrophobic
ARFORMOTEROL V114 3.33x33 TM3 Van der Waals
ARFORMOTEROL V117 3.36x36 TM3 hydrophobic
ARFORMOTEROL V117 3.36x36 TM3 Van der Waals
ARFORMOTEROL C191 45.50x50 ECL2 Van der Waals
ARFORMOTEROL D192 45.51x51 ECL2 Van der Waals
ARFORMOTEROL F193 45.52x52 ECL2 Van der Waals
ARFORMOTEROL F193 45.52x52 ECL2 hydrophobic
ARFORMOTEROL Y199 5.38x39 TM5 Van der Waals
ARFORMOTEROL A200 5.39x40 TM5 Van der Waals
ARFORMOTEROL S203 5.42x43 TM5 polar (hydrogen bond)
ARFORMOTEROL S203 5.42x43 TM5 polar (hydrogen bond)
ARFORMOTEROL S203 5.42x43 TM5 polar (hydrogen bond with backbone)
ARFORMOTEROL S207 5.46x461 TM5 Van der Waals
ARFORMOTEROL S207 5.46x461 TM5 polar (hydrogen bond)
ARFORMOTEROL F356 6.51x51 TM6 aromatic (edge-to-face)
ARFORMOTEROL F356 6.51x51 TM6 Van der Waals
ARFORMOTEROL F357 6.52x52 TM6 Van der Waals
ARFORMOTEROL F357 6.52x52 TM6 hydrophobic
ARFORMOTEROL N360 6.55x55 TM6 Van der Waals
ARFORMOTEROL N360 6.55x55 TM6 polar (hydrogen bond)
ARFORMOTEROL K372 7.32x31 TM7 Van der Waals
ARFORMOTEROL Y375 7.35x34 TM7 hydrophobic
ARFORMOTEROL Y375 7.35x34 TM7 Van der Waals
ARFORMOTEROL I376 7.36x35 TM7 hydrophobic
ARFORMOTEROL I376 7.36x35 TM7 Van der Waals
ARFORMOTEROL N379 7.39x38 TM7 polar (hydrogen bond)
ARFORMOTEROL Y383 7.43x42 TM7 Van der Waals

Ligands

ARFORMOTEROL

3D interaction viewer Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.


Residue Diagrams

V N G F V I A L V I L S M V I G M G V V 1 T S L A C A D L V M G A L V V P F G A A H 2 V C L T E I S A T V C L V D I S T W F E 3 A R V I I L M V W I V S G L T S F L P I 4 Y V F V M I V L P V Y F S V I S S A I A Y 5 G I I M G T F T L C W L P F F I V N I V 6 L P N F G S N V Y G I W N L L I Y V E 7
Download: PNG | SVG
ICL1 E R L Q ICL1ECL1 M W T F ECL1ICL2 P F K Y Q S L L ICL2ECL2 W Y R A T H Q E A I N C Y A N E T C C D F F T ECL2ICL3 G R F H V Q N L S Q V E Q D G R T G H G L R R S ICL3ECL3 D N L I ECL3N-term M G Q P G N G S A F L L A P N G S H A P D H D V T N-termC-term L R R S S L K A Y G N G Y S S N G N T G E Q S G Y H V E Q E K E N K L L C E D L P G T E D F V G H Q G T V P S D N I D S Q G R N C S T N D S L L C-term Q E R D E V W V V G M G I V M S L I V L A I V F G N V L V I T A I A K F T V T N Y F I T S L A C A D L V M G L A V V P F G A A H I L M K G N F W C E F W T S I D V L C V T A S I E T L C V I A V D R Y F A I T S T K N K A R V I I L M V W I V S G L T S F L P I Q M H N Q A Y A I A S S I V S F Y V P L V I M V F V Y S R V F Q E A K R Q L Q K I D K S E S K F C L K E H K A L K T L G I I M G T F T L C W L P F F I V N I V H V I Q R K E V Y I L L N W I G Y V N S G F N P L I Y C R S P D F Q E F R I A L L C
Download: PNG | SVG

Residue Table


GPCRdb(A)
GPCRdb(A)
β2-adrenoceptor
TM3
3x28 3.28x28 W109
3x32 3.32x32 D113
3x33 3.33x33 V114
3x36 3.36x36 V117
ECL2
45x50 45.50x50 C191
45x51 45.51x51 D192
45x52 45.52x52 F193
TM5
5x39 5.38x39 Y199
5x40 5.39x40 A200
5x43 5.42x43 S203
5x461 5.46x461 S207
TM6
6x51 6.51x51 F289
6x52 6.52x52 F290
6x55 6.55x55 N293
TM7
7x31 7.32x31 K305
7x34 7.35x34 Y308
7x35 7.36x35 I309
7x38 7.39x38 N312
7x42 7.43x42 Y316