Structure information

β2-adrenoceptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8JJL

SPECIES

Homo sapiens

RESOLUTION

3.200

PREFERRED CHAIN

A

REFERENCE

10.1038/S41589-023-01389-0

PUBLICATION DATE

Sept. 6, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
olodaterol W109 3.28x28 TM3 hydrophobic
olodaterol D113 3.32x32 TM3 polar (charge-assisted hydrogen bond)
olodaterol V114 3.33x33 TM3 hydrophobic
olodaterol V114 3.33x33 TM3 Van der Waals
olodaterol V117 3.36x36 TM3 hydrophobic
olodaterol V117 3.36x36 TM3 Van der Waals
olodaterol T118 3.37x37 TM3 Van der Waals
olodaterol D192 45.51x51 ECL2 polar (charge-assisted hydrogen bond)
olodaterol F193 45.52x52 ECL2 polar (hydrogen bond with backbone)
olodaterol F193 45.52x52 ECL2 Van der Waals
olodaterol Y199 5.38x39 TM5 Van der Waals
olodaterol A200 5.39x40 TM5 Van der Waals
olodaterol S203 5.42x43 TM5 polar (hydrogen bond)
olodaterol S207 5.46x461 TM5 Van der Waals
olodaterol S207 5.46x461 TM5 polar (hydrogen bond)
olodaterol W353 6.48x48 TM6 Van der Waals
olodaterol F356 6.51x51 TM6 aromatic (edge-to-face)
olodaterol F356 6.51x51 TM6 Van der Waals
olodaterol F357 6.52x52 TM6 aromatic (edge-to-face)
olodaterol F357 6.52x52 TM6 Van der Waals
olodaterol N360 6.55x55 TM6 Van der Waals
olodaterol N360 6.55x55 TM6 polar (hydrogen bond)
olodaterol Y375 7.35x34 TM7 Van der Waals
olodaterol Y375 7.35x34 TM7 hydrophobic
olodaterol I376 7.36x35 TM7 hydrophobic
olodaterol I376 7.36x35 TM7 Van der Waals
olodaterol N379 7.39x38 TM7 polar (hydrogen bond)
olodaterol Y383 7.43x42 TM7 Van der Waals

Ligands

olodaterol

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Residue Diagrams

V N G F V I A L V I L S M V I G M G V V 1 T S L A C A D L V M G A L V V P F G A A H 2 V C L T E I S A T V C L V D I S T W F E 3 A R V I I L M V W I V S G L T S F L P I 4 Y V F V M I V L P V Y F S V I S S A I A Y 5 G I I M G T F T L C W L P F F I V N I V 6 L P N F G S N V Y G I W N L L I Y V E 7
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ICL1 E R L Q ICL1ECL1 M W T F ECL1ICL2 P F K Y Q S L L ICL2ECL2 W Y R A T H Q E A I N C Y A N E T C C D F F T ECL2ICL3 G R F H V Q N L S Q V E Q D G R T G H G L R R S ICL3ECL3 D N L I ECL3N-term M G Q P G N G S A F L L A P N G S H A P D H D V T N-termC-term L R R S S L K A Y G N G Y S S N G N T G E Q S G Y H V E Q E K E N K L L C E D L P G T E D F V G H Q G T V P S D N I D S Q G R N C S T N D S L L C-term Q E R D E V W V V G M G I V M S L I V L A I V F G N V L V I T A I A K F T V T N Y F I T S L A C A D L V M G L A V V P F G A A H I L M K G N F W C E F W T S I D V L C V T A S I E T L C V I A V D R Y F A I T S T K N K A R V I I L M V W I V S G L T S F L P I Q M H N Q A Y A I A S S I V S F Y V P L V I M V F V Y S R V F Q E A K R Q L Q K I D K S E S K F C L K E H K A L K T L G I I M G T F T L C W L P F F I V N I V H V I Q R K E V Y I L L N W I G Y V N S G F N P L I Y C R S P D F Q E F R I A L L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
β2-adrenoceptor
TM3
3x28 3.28x28 W109
3x32 3.32x32 D113
3x33 3.33x33 V114
3x36 3.36x36 V117
3x37 3.37x37 T118
ECL2
45x51 45.51x51 D192
45x52 45.52x52 F193
TM5
5x39 5.38x39 Y199
5x40 5.39x40 A200
5x43 5.42x43 S203
5x461 5.46x461 S207
TM6
6x48 6.48x48 W286
6x51 6.51x51 F289
6x52 6.52x52 F290
6x55 6.55x55 N293
TM7
7x34 7.35x34 Y308
7x35 7.36x35 I309
7x38 7.39x38 N312
7x42 7.43x42 Y316