Structure information

NTS1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8JPF

SPECIES

Homo sapiens

RESOLUTION

3.020

PREFERRED CHAIN

R

REFERENCE

10.1038/S41586-023-06395-9

PUBLICATION DATE

Aug. 9, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
JMV431 L54 N-term Van der Waals
JMV431 L54 N-term polar (hydrogen bond with backbone)
CHEMBL4576388 L105 2.43x43 TM2 hydrophobic
JMV431 H132 ECL1 Van der Waals
JMV431 Y145 3.29x29 TM3 polar (hydrogen bond)
JMV431 Y145 3.29x29 TM3 polar (hydrogen bond)
CHEMBL4576388 V159 3.43x43 TM3 hydrophobic
CHEMBL4576388 L162 3.46x46 TM3 hydrophobic
CHEMBL4576388 R166 3.50x50 TM3 polar (charge-assisted hydrogen bond)
CHEMBL4576388 I170 3.54x54 TM3 Van der Waals
CHEMBL4576388 I170 3.54x54 TM3 hydrophobic
JMV431 M207 4.64x65 TM4 Van der Waals
JMV431 V223 ECL2 hydrophobic
JMV431 T225 45.51x51 ECL2 polar (hydrogen bond)
JMV431 T225 45.51x51 ECL2 Van der Waals
JMV431 I237 5.39x40 TM5 hydrophobic
JMV431 I237 5.39x40 TM5 Van der Waals
CHEMBL4576388 N256 5.58x58 TM5 Van der Waals
CHEMBL4576388 L305 6.37x37 TM6 hydrophobic
CHEMBL4576388 L305 6.37x37 TM6 Van der Waals
CHEMBL4576388 V308 6.40x40 TM6 hydrophobic
CHEMBL4576388 V308 6.40x40 TM6 Van der Waals
JMV431 R322 6.54x54 TM6 polar (charge-assisted hydrogen bond)
JMV431 R323 6.55x55 TM6 Van der Waals
JMV431 F326 6.58x58 TM6 Van der Waals
JMV431 F326 6.58x58 TM6 polar (hydrogen bond with backbone)
JMV431 I329 ECL3 Van der Waals
JMV431 I329 ECL3 polar (hydrogen bond with backbone)
JMV431 W334 ECL3 Van der Waals
JMV431 W334 ECL3 hydrophobic
JMV431 P336 7.25x24 TM7 Van der Waals
JMV431 Y339 7.28x27 TM7 hydrophobic
JMV431 Y339 7.28x27 TM7 Van der Waals
JMV431 Y342 7.31x30 TM7 Van der Waals
JMV431 Y342 7.31x30 TM7 polar (hydrogen bond)
JMV431 H343 7.32x31 TM7 Van der Waals
JMV431 Y346 7.35x34 TM7 polar (hydrogen bond)
JMV431 Y346 7.35x34 TM7 Van der Waals
CHEMBL4576388 V367 7.56x56 TM7 hydrophobic
CHEMBL4576388 V367 7.56x56 TM7 Van der Waals
CHEMBL4576388 F371 8.50x50 H8 Van der Waals
CHEMBL4576388 F371 8.50x50 H8 hydrophobic

Ligands

JMV431

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CHEMBL4576388

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Residue Diagrams

T N G V T G V V F L A L Y V A T V L V K 1 G S L A L S D L L T L L L A M P V E L Y N 2 S A V N L A T A Y T C A D R L F Y Y G R 3 T K K F I S A I W L A S A L L A V P M 4 N L V S I V V M P F I F S M F T N V Q I V 5 R A V V I A F V V C W L P Y H V R R L M 6 I P N I T S S V Y F L A N T V M Y F Y 7
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ICL1 K S L Q ICL1ECL1 H H P W A F ECL1ICL2 P F K A K T L M ICL2ECL2 G E Q N R S A D G Q H A G G L V C T P T I ECL2ICL3 Q V C T V G G E H S T F S M A I E ICL3ECL3 S D E Q W ECL3N-term M R L N S S A P G T P G T P A A D P F Q R A Q A G L E E A L L A P G F G N A S G N A S E R V L A A P S S E L D V N T N-termC-term P V W R R R R K R P A F S R K A D S V S S N H T L S S N A T R E T L Y C-term D I Y S K V L V T A V Y L A L F V V G T V G N T V T A F T L A R K S L Q S T V H Y H L G S L A L S D L L T L L L A M P V E L Y N F I W V G D A G C R G Y Y F L R D A C T Y A T A L N V A S L S V E R Y L A I C H S R S R T K K F I S A I W L A S A L L A V P M L F T M H T A T V K V V I Q V N T F M S F I F P M V V I S V L N T I I A N K L T V M V R Q A A E Q G P G R V Q A L R H G V R V L R A V V I A F V V C W L P Y H V R R L M F C Y I T P F L Y D F Y H Y F Y M V T N A L F Y V S S T I N P I L Y N L V S A N F L A L C F R H I T L A C
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Residue Table


GPCRdb(A)
GPCRdb(A)
NTS1 receptor
TM2
2x43 2.43x43 L105
TM3
3x29 3.29x29 Y145
3x43 3.43x43 V159
3x46 3.46x46 L162
3x50 3.50x50 R166
3x54 3.54x54 I170
TM4
4x65 4.64x65 M207
ECL2
45x51 45.51x51 T225
TM5
5x40 5.39x40 I237
5x58 5.58x58 N256
TM6
6x37 6.37x37 L305
6x40 6.40x40 V308
6x54 6.54x54 R322
6x55 6.55x55 R323
6x58 6.58x58 F326
TM7
7x24 7.25x24 P336
7x27 7.28x27 Y339
7x30 7.31x30 Y342
7x31 7.32x31 H343
7x34 7.35x34 Y346
7x56 7.56x56 V367
H8
8x50 8.50x50 F371