Structure information

PTH1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

8JR9

SPECIES

Homo sapiens

RESOLUTION

2.570

PREFERRED CHAIN

R

REFERENCE

10.1038/S41586-023-06467-W

PUBLICATION DATE

Aug. 2, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
PCO371 R219 2.46x46 TM2 polar (charge-assisted hydrogen bond)
PCO371 H223 2.50x50 TM2 aromatic (face-to-face)
PCO371 H223 2.50x50 TM2 polar (hydrogen bond)
PCO371 L226 2.53x53 TM2 Van der Waals
PCO371 I299 3.47x47 TM3 Van der Waals
PCO371 E302 3.50x50 TM3 polar (charge-assisted hydrogen bond)
PCO371 L306 3.54x54 TM3 Van der Waals
PCO371 N374 5.50x50 TM5 Van der Waals
PCO371 L411 6.43x43 TM6 Van der Waals
PCO371 V412 6.44x44 TM6 Van der Waals
PCO371 L413 6.45x45 TM6 Van der Waals
PCO371 M414 6.46x46 TM6 polar (hydrogen bond with backbone)
PCO371 M414 6.46x46 TM6 Van der Waals
PCO371 P415 6.47x47 TM6 polar (hydrogen bond with backbone)
PCO371 P415 6.47x47 TM6 Van der Waals
PCO371 L416 6.48x48 TM6 polar (hydrogen bond with backbone)
PCO371 L416 6.48x48 TM6 Van der Waals
PCO371 F417 6.49x49 TM6 hydrophobic
PCO371 F417 6.49x49 TM6 Van der Waals
PCO371 I458 7.56x56 TM7 polar (hydrogen bond with backbone)
PCO371 I458 7.56x56 TM7 Van der Waals
PCO371 Y459 7.57x57 TM7 polar (hydrogen bond)
PCO371 Y459 7.57x57 TM7 polar (hydrogen bond with backbone)
PCO371 N463 8.47x47 H8 polar (hydrogen bond)
PCO371 N463 8.47x47 H8 polar (hydrogen bond)

Ligands

PCO371

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Residue Diagrams

T L S A L S V S Y G V T Y I M G L R D F 1 M H L F L S F M L R A V S I F V K D A V 2 V L I W Y Y N T A L F Y L F F T V A V R 3 Y L W G F T V G F W G L P A V F V A V W V 4 F L I F N L V I S A L I P V Q I I W K K N 5 L V L M P L F G V H Y I V F M A T 6 I A V F F G Q F S N F L M E Y H M Q V 7
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ICL1 R R L H ICL1ECL1 L D E A E R L T E E E L R A I A Q A P P P P A T A A A ECL1ICL2 A F F ICL2ECL2 N T G C W D L S S ECL2ICL3 R E T N A G R C ICL3ECL3 P Y T E V S ECL3N-term M G T A R I A P G L A L L L C C P V L S S A Y A L V D A D D V M T K E E Q I F L L H R A Q A Q C E K R L K E V L Q R P A S I M E S D K G W T S A S T S G K P R K D K A S G K L Y P E S E E D K E A P T G S R Y R G R P C L P E W D H I L C W P L G A P G E V V A V P C P D Y I Y D F N H K G H A Y R R C D R N G S W E L V P G H N R T W A N Y S E C V K N-termC-term S G S S S Y S Y G P M V S H T S V T N V G P R V G L G L P L S P R L L P T A T T N G H P Q L P G H A K P G T P A L E T L E T T P P A M A A P K D D G F L N G S C S G L D E E A S G P E R P P A L L Q E E W E T V M C-term F L T N E T R E R E V F D R L G M I Y T V G Y S V S L A S L T V A V L I L A Y F C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S G A T G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L D T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T G T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E I K K W T L K R K V Q A E S W S R A L D F A R
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Residue Table


GPCRdb(A)
GPCRdb(B)
PTH1 receptor
TM2
2x39 2.46x46 R219
2x43 2.50x50 H223
2x46 2.53x53 L226
TM3
3x43 3.47x47 I299
3x46 3.50x50 E302
3x50 3.54x54 L306
TM5
5x54 5.50x50 N374
TM6
6x38 6.43x43 L411
6x39 6.44x44 V412
6x40 6.45x45 L413
6x41 6.46x46 M414
6x42 6.47x47 P415
6x43 6.48x48 L416
6x44 6.49x49 F417
TM7
7x52 7.56x56 I458
7x53 7.57x57 Y459
H8
8x47 8.47x47 N463