PDB
8JRV
Resolution
3.3 Å
Released
Aug. 16, 2023
Receptor
glucagon
Class
B1
Species
Homo sapiens
Ligand
Function
Glucagon
Agonist
Reference
10.1038/S41586-023-06420-X

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Ligand Amino Acid Generic Number Segment Interaction Type
Glucagon V28 N-term Van der Waals
Glucagon M29 N-term Van der Waals
Glucagon Y138 1.36x36 TM1 hydrophobic
Glucagon Y138 1.36x36 TM1 aromatic (edge-to-face)
Glucagon L198 2.71x71 TM2 hydrophobic
Glucagon Y202 2.75x75 TM2 hydrophobic
Glucagon K205 2.78x78 TM2 hydrophobic
Glucagon W304 5.36x37 TM5 Van der Waals
Glucagon L382 7.39x38 TM7 Van der Waals

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ICL1 S K L H ICL1ECL1 Q K I G D D L S V S T W L S D G ECL1ICL2 A T L P E R ICL2ECL2 N V Q C W T S N D N M G F ECL2ICL3 R Q M H H T ICL3ECL3 E H A Q ECL3N-term M P P C Q P Q R P L L L L L L L L A C Q P Q V P S A Q V M D F L F E K W K L Y G D Q C H H N L S L L P P P T E L V C N R T F D K Y S C W P D T P A N T T A N I S C P W Y L P W H H K V Q H R F V F K R C G P D G Q W V R G P R G Q P W R D A S Q C Q M D G E E I E V N-termC-term T S N H R A S S S P G H G P P S K E L Q F G R G G G S Q D S S A E T P L A G G L P R L A E S P F C-term Q K E V A K M Y S S F Q V M Y T V G Y S L S L G A L L L A L A I L G G L C T R N A I H A N L F A S F V L K A S S V L V I D G L L R T R Y S A V A G C R V A A V F M Q Y G I V A N Y C W L L V E G L Y L H N L L G L S F F S L Y L G I G W G A P M L F V V P W A V V K C L F E W W I L R F P V F L A I L I N F F I F V R I V Q L L V A K L R A D Y K F R L A K S T L T L I P L L G V H E V V F A F V T D G T L R S A K L F F D L F L S S F Q G L L V A V L Y C F L N K E L R R W R L W E E V Q S E R W H R G K V L R N
Helix box plot — Download: PNG | SVG L L A G L S L S Y G V T Y M V Q F S S Y 1 A N L F A S F V L K A S S V L V I D G L 2 V L L W C Y N A V I G Y Q M F V A A V R 3 F F S L Y L G G I W G A P M L F V V P W A 4 F I F F N I L I A L F V P F R L I W W 5 L T L I P L L G V H E V V F A F V T D 6 V A V L L G Q F S S L F L D F F L K A 7

GPCRdb(A)
GPCRdb(B)
glucagon receptor
TM1
1x32 1.36x36 Y138
TM2
2x64 2.71x71 L198
2x68 2.75x75 Y202
TM5
5x41 5.36x37 W304
TM7
7x34 7.39x38 L382